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Merck

P3076

Platelet-Derived Growth Factor-AA human

PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

PDGF−AA

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00081862
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥98% (SDS-PAGE and HPLC)
Form:
lyophilized powder
Mol wt:
28.5 kDa (containing 250 amino acid residues)
Impurities:
<1 EU/μg

Key Documents

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Product Name

Platelet-Derived Growth Factor-AA human, PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

human

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE and HPLC)

form

lyophilized powder

quality

endotoxin tested

mol wt

28.5 kDa (containing 250 amino acid residues)

packaging

pkg of 10 μg
pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

<1 EU/μg

UniProt accession no.

P04085

storage temp.

−20°C

Quality Level

100

Gene Information

human ... PDGFRA(5154)

potency

≤1.0-3.0 ng/mL ED50

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Other Notes

Homodimer of the A chain of human PDGF.

Analysis Note

The biological activity is measured by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells.

Biochem/physiol Actions

Cell division and relocalization of pulmonary artery smooth muscle cells and fibroblasts is known to be triggered by platelet-derived growth factor (PDGF). Due to its proliferatory function, it is associated with fibroproliferative disorders such as atherosclerosis, pulmonary arterial hypertension and lung fibrosis. PDGF exists both in homo and heterodimeric forms and stimulates α and β-cell surface receptors. Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo.

General description

Platelet-derived growth factor (PDGF) is composed two polypeptide subunits of A and B chain. PDGF is produced by a number of cells including smooth muscle cells, endothelial cells and macrophages. The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3. PDGF is structurally and functionally related to vascular endothelial growth factors.

Physical form

Sterile-filtered through a 0.2 μm filter. Lyophilized with 10 mM acetic acid.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ3327
MKCZ0119
MKCT3164
MKCS6685
MKCR9071

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Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non?small cell lung carcinomas.
Shikada Y, et al.
Cancer Research, 65.16, 7241-7248 (2005)
Role of platelet-derived growth factors in physiology and medicine.
Andrae J, et al.
Genes & Development, 22.10, 1276-1312 (2008)
Clinical Findings Associated with a De Novo Partial Trisomy 10p11. 22p15. 3 and Monosomy 7p22. 3 Detected by Chromosomal Microarray Analysis.
Kohannim O, et al.
Case Reports in Genetics, 2011 (2011)
Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension.
Perros F, et al.
American Journal of Respiratory and Critical Care Medicine, 178.1, 81-88 (2008)
Neha Garg et al.
The EMBO journal, 32(21), 2819-2832 (2013-10-01)
The transcription factor Nanog plays a critical role in the self-renewal of embryonic stem cells as well as in neural stem cells (NSCs). microRNAs (miRNAs) are also involved in stemness regulation. However, the miRNA network downstream of Nanog is still
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Data Sheet - P3076

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