SML1169
Pitstop 2
≥98% (HPLC), powder, clathrin-mediated endocytosis inhibitor
Synonym(s):
N-[5-[(4-Bromophenyl)methylene]-4,5-dihydro-4-oxo-2-thiazolyl]-1-naphthalenesulfonamide, Pitstop-2
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About This Item
Empirical Formula (Hill Notation):
C20H13BrN2O3S2
CAS Number:
Molecular Weight:
473.36
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
Pitstop 2, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
Related Categories
Application
Pitstop 2 has been used as an inhibitor of clathrin-mediated endocytosis.
Biochem/physiol Actions
Pitstop 2 also has an ability to breakdown the nuclear pore complex (NPC) permeability barrier and decrease importin β binding along with alteration of the NPC ultrastructure. Pitstop 2 is also involved in the inhibition of platelet activation, platelet aggregation and secretion.
Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis that acts via blocking ligand access to the clathrin terminal domain. Pitstop 2 selectively inhibits clathrin-mediated HIV entry and stalls clathrin-coated pit (CCP) dynamics.
Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Clathrin inhibitor Pitstop-2 disrupts the nuclear pore complex permeability barrier
Liashkovich I, et al.
Scientific Reports, 5, 9994-9994 (2015)
Leucine-rich repeat-containing G protein?coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein
Zhang N, et al,
The Journal of Biological Chemistry, 292(40), 16527-16538 (2017)
Muhammad Asam Riaz et al.
Journal of proteomics, 227, 103918-103918 (2020-07-28)
Bacterial insecticidal proteins, such as the Bin toxin from Lysinibacillus sphaericus, could be used more extensively to control insecticide resistant mosquitoes. This study was aimed at identification of mosquito cell proteins binding Bin toxin. Results showed that purified toxin was
Clathrin-mediated integrin ?IIb?3 trafficking controls platelet spreading
Gao W, et al.
Platelets, 1-12 (2017)
Er-Wen Huang et al.
Atherosclerosis, 254, 133-141 (2016-10-16)
Macrophage-derived foam cell formation (MFCF) is a crucial step in the pathogenesis of atherosclerosis. Uptake of oxidized low-density lipoprotein (oxLDL) by scavenger receptors is indispensable for MFCF. Endophilin-A2 has been reported to regulate clathrin-mediated endocytosis (CME). In this study, we
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