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Merck

1148089

USP

Collagenase I

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Collagenase from Clostridium histolyticum, Clostridiopeptidase A

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About This Item

CAS Number:
9001-12-1
UNSPSC Code:
41116107
NACRES:
NA.24
EC Number:
3.4.24.3 (BRENDA, IUBMB)
MDL number:
MFCD00130830

Product Name

Collagenase I, United States Pharmacopeia (USP) Reference Standard

grade

pharmaceutical primary standard

form

liquid

manufacturer/tradename

USP

application(s)

USP Biologics
pharmaceutical

format

neat

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Other Notes

Sales restrictions may apply.
This product is part of the USP Biologics program.
One collagen digestion unit (CDU) liberates peptides from collagen from bovine achilles tendon equivalent in ninhydrin color to 1.0 μmole of leucine in 5 hours at pH 7.4 at 37 °C in the presence of calcium ions. One FALGPA hydrolysis unit hydrolyzes 1.0 μmole of furylacryloyl-Leu-Gly-Pro-Ala per min at 25°C. One Neutral Protease unit hydrolyzes casein to produce color equivalent to 1.0 μmole of tyrosine per 5 hr at pH 7.5 at 37°C. One Clostripain Unit hydrolyzes 1.0 μmole of BAEE per min at pH 7.6 at 25°C in the presence of DTT.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Biochem/physiol Actions

Collagenase is activated by four gram atom calcium per mole enzyme. It is inhibited by ethylene glycol-bis(beta-aminoethyl ether) - N, N, N′,N′-tetraacetic acid, beta-mercaptoethanol, glutathione, thioglycolic acid and 8-hydroxyquinoline.

General description

Collagenase I is an enzyme that breaks down collagen, a primary structural protein in connective tissues. It is used in various medical and research applications, including tissue dissociation and wound debridement.​

The USP Collagenase I standard provides a benchmark for the activity and purity of collagenase I, ensuring its efficacy and safety in therapeutic and laboratory settings.

The USP biologics proteins category provides critical standards and reference materials necessary for the development and manufacturing of therapeutic proteins. These proteins, which can be naturally derived or genetically engineered, are essential in treating various diseases and conditions, ensuring that they meet quality, safety, and efficacy standards.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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