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Merck

681660-M

N-WASP-Inhibitor, 187-1

The N-WASP-Inhibitor, 187-1 controls the biological activity of neural Wiskott Aldrich syndrome protein (N-WASP). This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

N-WASP-Inhibitor, 187-1, cyclo( LK DF DP DF LF DP LQ)2

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About This Item

Empirical Formula (Hill Notation):
C96H122N18O16
Molecular Weight:
1784.11
UNSPSC Code:
12352200
NACRES:
NA.77

Product Name

N-WASP-Inhibitor, 187-1, The N-WASP-Inhibitor, 187-1 controls the biological activity of neural Wiskott Aldrich syndrome protein (N-WASP). This small molecule/inhibitor is primarily used for Cell Structure applications.

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

DMSO: 1 mg/mL
acetic acid: 5%

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Primary Target
Neural Wiskott Aldrich syndrome protein (N-WASP)
Target IC50: ~ 2 µM blocking phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract

Disclaimer

Toxicity: Standard Handling (A)

General description

A 14-amino acid cyclic peptide that potently blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract (IC50 ~2 µM). Shown to directly bind to neural Wiskott Aldrich syndrome protein (N-WASP) with high-affinity, and allosterically stabilize the autoinhibited conformation of N-WASP. It prevents the activation of actin-related protein 2/3 (Arp2/3) complex by blocking the interaction between N-WASP and Arp2/3.

Other Notes

Peterson, J.R., et al. 2001. Proc. Natl. Acad. Sci. USA98, 10624.
Suetsugu, S., et al. 2001. J. Biol. Chem.276, 33175.
cyclo(LLys-DPhe-DPro-DPhe-LPhe-DPro-LGln)₂

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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