N4126
Nicotinic acid
≥98%
Synonym(s):
3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B3
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About This Item
Empirical Formula (Hill Notation):
C6H5NO2
CAS Number:
Molecular Weight:
123.11
UNSPSC Code:
12352106
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-441-0
Beilstein/REAXYS Number:
109591
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥98%
form
powder
color
white to off-white
mp
236-239 °C (lit.)
SMILES string
OC(=O)c1cccnc1
InChI
1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
InChI key
PVNIIMVLHYAWGP-UHFFFAOYSA-N
Gene Information
human ... CYP1A2(1544)
rat ... Chrnb2(54239)
General description
Nicotinic acid is also known as vitamin B3 or Niacin. It is a water soluble vitamin. Niacin can be either synthesized within the body or can be obtained from dietary sources.
Application
Nicotinic acid has been used:
- as a component of the MS vitamins stock solution
- for the detection of siderophores in Escherichia coli bacterial culture
- as a component of the holidic medium for adult Drosophila .
Biochem/physiol Actions
Niacin is involved in the production of nicotinamide adenine dinucleotide (NAD+), which is used in the adenine triphosphate (ATP) production in mitochondrial oxidative phosphorylation. It also decreases hepatic production of very-low density lipoproteins (VLDL), and apolipoprotein B (apo-B). Niacin deficiency leads to pellagra.
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
379.4 °F - closed cup
flash_point_c
193 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Vitamin B3 and sirtuin function
Denu J M
Trends in Biochemical Sciences, 30(9), 479-483 (2005)
A holidic medium for Drosophila melanogaster
Piper M D W, et al.
Nature Methods, 11(1), 100-100 (2014)
A procedure allowing up to eight generations of wheat and nine generations of barley per annum
Zheng Z, et al.
Euphytica, 191(2), 311-316 (2013)