Skip to Content
Merck

Key Documents

View All Documentation

15759

Poloxamer 188

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lutrol F68

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

CAS Number:
9003-11-6
UNSPSC Code:
12352104
NACRES:
NA.25
MDL number:
MFCD00082049
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

form

solid

Quality Level

200

mol wt

~7680-9510 g/mol

composition

oxyethylene, 79.9-83.7%

impurities

≤0.25% ethylene glycol and diethylene glycol, ≤0.4% total ash, ≤1 ppm ethylene oxide, ≤1.0% water, ≤2 ppm arsenic traces, ≤20 ppm heavy metals, ≤5 ppm dioxan, ≤5 ppm propylene oxide, 50-150 ppm butylhydroxytoluene

ign. residue

≤0.30%

color

APHA: ≤120, 50/50 in CH3OH

pH

5.0-7.5 (100 g/L in H2O), 6.0-7.5 (25 g/L in H2O)

CMC

0.48 mM

transition temp

cloud point >100 °C

HLB

>24

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

Application


  • Stabilizing Function of P 188 in Dermal Formulations: Examined for its stabilizing effects on industrial concentrates of dermal hesperidin smartCrystals, P 188 contributed to enhancing the long-term stability of the formulations, relevant for dermal therapeutic interventions (Romero et al., 2015).

Biochem/physiol Actions

Poloxamer 188 is widely used as a thickening agent and gel binder.

Other Notes

The Poloxamer 188 grades are poloxamers from the extensive line of block copolymers.

Legal Information

Still not finding the right product?

Explore all of our products under Poloxamer 188

Storage Class

11 - Combustible Solids

wgk

WGK 1

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCN6034
BCCN6032
BCCN0958
BCCL8783
BCCM5491

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Tsz Chung Lai et al.
Colloids and surfaces. B, Biointerfaces, 99, 27-37 (2011-10-18)
Polyplex particles formed with plasmid DNA (pDNA) and Pluronic P85-block-poly{N-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} (P85-b-P[Asp(DET)]) demonstrated highly effective transfection ability compared to PEG-based block cationomer, PEG-b-P[Asp(DET)]. Ternary polyplexes comprising PEG-b-P[Asp(DET)], poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-b-P[Asp(DET)] (P(EPE)-b-P[Asp(DET)]) used as an analog of P85-b-P[Asp(DET)], and pDNA were
Xijun Zhang et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 31(6), 842-845 (2011-12-17)
This study examined the effect of P85 (a pluronic block copolymer) and microbubble (MB) ultrasound contrast agents under ultrasound irradiation on gene transfection and expression. The pEGFP plasmids that can encode enhanced green fluorescent protein (pEGFP) served as a report
A N Sklifas et al.
Biofizika, 57(2), 317-324 (2012-05-19)
The adsorption abilities of the perfluorocarbon emulsion stabilized by Proxanol 268 were investigated in vitro and in vivo. In vitro, the saturation point for the blood plasma proteins was nearly reached after five minutes of incubation of the emulsion with
View All Related Papers