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F9381

Fluorometholone

≥98%

Synonym(s):

11β,17α-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C22H29FO4
CAS Number:
426-13-1
Molecular Weight:
376.46
EC Number:
207-041-5
NACRES:
NA.77
PubChem Substance ID:
24894996
UNSPSC Code:
12352212
MDL number:
MFCD00056461
Assay:
≥98%
Quality level:
200
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Quality Level

200

assay

≥98%

SMILES string

C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(C)=O)[C@@]3(C)C[C@H](O)[C@]2(F)[C@@]4(C)C=CC(=O)C=C14

InChI

1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1

InChI key

FAOZLTXFLGPHNG-KNAQIMQKSA-N

Gene Information

human ... NR3C1(2908)

Application


  • Topical fluorometholone treatment and desiccating stress change inflammatory protein expression in tears.: This research explores the changes in tear protein expression due to topical fluorometholone and environmental stress, offering insights into ocular surface inflammatory responses (Nättinen et al., 2018).

  • General Pharmacokinetic Model for Topically Administered Ocular Drug Dosage Forms.: This study provides a pharmacokinetic model applicable to topical ocular medications, including fluorometholone, enhancing understanding of drug dynamics in eye treatments (Deng et al., 2016).

Biochem/physiol Actions

Clinically significant in allergic conjunctivitis and as anti-inflammatory following cataract surgery.

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GHS07

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Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000546551
0000546550
0000534604
0000546551
0000546550

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Miguel Naveiras et al.
American journal of ophthalmology, 153(5), 958-966 (2012-01-31)
To describe the incidence and causes of glaucoma after Descemet membrane endothelial keratoplasty (DMEK). Nonrandomized prospective cohort study at a tertiary referral center. The incidence of glaucoma was evaluated in the first 275 consecutive eyes that underwent DMEK for Fuchs
Lei Zhu et al.
Molecular vision, 18, 1803-1812 (2012-07-21)
To evaluate the effect of the topical steroid, fluorometholone, and the non-steroidal anti-inflammatory drugs (NSAIDs), nepafenac and ketorolac, on inflammatory cytokine expression of the ocular surface in the botulium toxin B-induced murine dry eye model. Topical artificial tears (0.5% carboxymethylcellulose
Deniz Hos et al.
Archives of ophthalmology (Chicago, Ill. : 1960), 129(4), 445-452 (2011-04-13)
To analyze whether topical application of corticosteroids inhibits inflammatory corneal lymphangiogenesis and to study the potential underlying antilymphangiogenic mechanisms. Inflammatory corneal neovascularization was induced by suture placement, and the corneas were then treated with topical fluorometholone, prednisolone acetate, or dexamethasone
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