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G7637

Guanosine 5′-[β-thio]diphosphate trilithium salt

≥85% (HPLC), G-protein inhibitor, powder

Synonym(s):

GDPβS trilithium salt, GDP-β-S, GDP-β-S-Li3

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About This Item

Empirical Formula (Hill Notation):
C10H12Li3N5O10P2S
CAS Number:
97952-36-8
Molecular Weight:
477.07
NACRES:
NA.77
PubChem Substance ID:
329799966
UNSPSC Code:
41106305
MDL number:
MFCD00057735
Beilstein/REAXYS Number:
8181243
Assay:
≥85% (HPLC)
Form:
powder
Quality level:
200
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Product Name

Guanosine 5′-[β-thio]diphosphate trilithium salt, ≥85% (HPLC), powder

Quality Level

200

assay

≥85% (HPLC)

form

powder

color

white

solubility

H2O: 20 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Li+].[Li+].[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H15N5O10P2S.3Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(24-9)1-23-26(19,20)25-27(21,22)28;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H2,21,22,28)(H3,11,13,14,18);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1

InChI key

LMCWQGPJYZRMKU-CYCLDIHTSA-K

Application

Guanosine 5′-[β-thio]diphosphate trilithium salt has been used as an inhibitor of G-protein activation to study its effects on acetylcholine current in bag cell neurons. It has also been used to study its effects on cholinergic-dependent plateau potentials.

Biochem/physiol Actions

Guanosine 5′-[β-thio]diphosphate is a non-hydrolyzable analog of guanosine. It functions as an inhibitor of G-protein activation.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

Non-hydrolyzable GDP analog

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM4152
BCCJ6754
BCCH5337
BCCH0398
BCCC7403

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R J Ho et al.
Archives of biochemistry and biophysics, 251(1), 148-155 (1986-11-15)
Forskolin-activated adenylate cyclases (AC) in intact membranes, solubilized with Lubrol or eluted following adsorption on a forskolin-Sepharose column, were examined for inhibition by GDP and GDP beta S. AC in intact membranes of rat or rabbit adipocytes was activated by
A K H Tam et al.
Neuroscience, 179, 41-55 (2011-02-01)
Targeting signalling molecules to ion channels can expedite regulation and assure the proper transition of changes to excitability. In the bag cell neurons of Aplysia, single-channel studies of excised patches have revealed that protein kinase C (PKC) gates a non-selective
E Oberdisse et al.
Biochemical and biophysical research communications, 144(3), 1188-1196 (1987-05-14)
Guanosine 5'-O-thiotriphosphate (GTP gamma S) and thrombin stimulate the activity of phospholipase C in platelets that have been permeabilized with saponin and whose inositol phospholipids have been prelabeled with [3H]inositol. Ca2+ has opposite effects on the formation of [3H]inositol phosphates
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