T0875
Sodium taurodeoxycholate hydrate
≥95% (HPLC)
Synonym(s):
2-([3α,12α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid, Taurodeoxycholic acid sodium salt hydrate
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About This Item
Linear Formula:
C26H44NO6SNa · xH2O
CAS Number:
Molecular Weight:
521.69 (anhydrous basis)
UNSPSC Code:
12161900
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3901204
description
anionic
assay
≥95% (HPLC)
mol wt
micellar avg mol wt 3100
aggregation number
6
CMC
1-4 mM (20-25°C)
application(s)
sample preservation
Quality Level
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Application
Bile salt-related, anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins.
Sodium taurodeoxycholate hydrate has been used in a study to assess the effect of submicellar concentrations of bile salts on the lipid bilayer membrane. It has also been used in a study to investigate polymorphic behavior in protein-surfactant mixtures.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Jing-Yi Ye et al.
International journal of nanomedicine, 15, 6503-6518 (2020-09-15)
A non-lipolysis nanoemulsion (NNE) was designed to reduce the first-pass metabolism of raloxifene (RAL) by intestinal UDP-glucuronosyltransferases (UGTs) for increasing the oral absorption of RAL, coupled with in vitro and in vivo studies. In vitro stability of NNE was evaluated
Barbara Orioni et al.
The journal of physical chemistry. B, 110(24), 12129-12140 (2006-06-28)
Mixtures containing water, bovine serum albumin (BSA), and sodium taurodeoxycholate (NaTDC), a component of the bile in mammals, have been investigated in a wide range of composition and pH. Depending on the concentration of both solutes and the pH, solutions
Blanca Cervantes et al.
Journal of clinical medicine, 8(9) (2019-09-22)
Cisplatin is a chemotherapeutic agent that causes the irreversible death of auditory sensory cells, leading to hearing loss. Local administration of cytoprotective drugs is a potentially better option co-therapy for cisplatin, but there are strong limitations due to the difficulty
Malinda Salim et al.
Molecular pharmaceutics, 17(3), 885-899 (2020-02-06)
Techniques enabling in situ monitoring of drug solubilization and changes in the solid-state of the drug during the digestion of milk and milk-based formulations are valuable for predicting the effectiveness of such formulations in improving the oral bioavailability of poorly
Xiao-Feng Zhang et al.
Food chemistry, 274, 305-313 (2018-10-31)
The low expression level of acidic lipases from Aspergillus sp. remains a major obstacle for their use in industrial applications. In this study, fusion expression with three fusion partners was investigated to enhance the expression level of an acidic lipase
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