T3516

Thioflavin T

Name: Thioflavin T
Brand: SIGMA

Powder

Synonym(s):

Basic Yellow 1, Thioflavine T

Select a Size

All Photos(4)

About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₉ClN₂S

CAS Number:

2390-54-7

Molecular Weight:

318.86

UNSPSC Code:

12171500

NACRES:

NA.47

PubChem Substance ID:

24900146

EC Number:

219-228-9

MDL number:

MFCD00011944

Colour Index Number:

49005

Beilstein/REAXYS Number:

3922452

Product Name

Thioflavin T, used as stain for amyloid

InChI

1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1

InChI key

JADVWWSKYZXRGX-UHFFFAOYSA-M

SMILES string

[Cl-].CN(C)c1ccc(cc1)-c2sc3cc(C)ccc3[n+]2C

form

powder

composition

Dye content, ≥65%

solubility

methanol: 1 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

200

Looking for similar products? Visit Product Comparison Guide

Related Categories

Clinical & Diagnostics

Hematology Stains

Histology Stains

Tissue Diagnostics

Application

Thioflavin T has been used to identify the presence of amyloid fibrils in samples.

General description

Thioflavin T is a benzothiazole dye that increases in fluorescence upon binding to amyloid. Thioflavin T has been used in histology and for protein characterization.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

GHS06,GHS05,GHS09

signalword

Danger

hcodes

H301,H317,H318,H410

pcodes

P261 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Mechanism of thioflavin T binding to amyloid fibrils.

Ritu Khurana et al.

Journal of structural biology, 151(3), 229-238 (2005-08-30)

Thioflavin T is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, thioflavin T was found to exist as micelles

A DNA nanoswitch-controlled reversible nanosensor.

Pai Peng et al.

Nucleic acids research, 45(2), 541-546 (2016-12-03)

We present a conceptually new reversible nanosensor regulated by a DNA nanoswitch. This system is not only responsive to external stimuli (e.g. ATP) but also can be reversibly switched between 'OFF' and 'ON' states via toehold mediated strand displacement reactions.

Extrinsic fluorescent dyes as tools for protein characterization.

Hawe, A., et al.

Pharmaceut. Res., 25, 1487-1499 (2008)

Molecular mechanism of Thioflavin-T binding to amyloid fibrils.

Matthew Biancalana et al.

Biochimica et biophysica acta, 1804(7), 1405-1412 (2010-04-20)

Intense efforts to detect, diagnose, and analyze the kinetic and structural properties of amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes. Since its first description in 1959, the fluorescent dye Thioflavin-T (ThT) has become among the most

Tracking Aggregation and Fibrillation of Globular Proteins Using Terahertz and Far-Infrared Spectroscopies

Gretel Png

Taiwan yi Xue Hui za Zhi. Journal of the Formosan Medical Association (2016)

View All Related Papers