U0750

Uracil

Name: Uracil
Brand: SIGMA

≥99.0%, synthetic (organic), powder

Synonym(s):

2,4(1H,3H)-Pyrimidinedione, 2,4-Dihydroxypyrimidine, 2,4-Pyrimidinediol

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About This Item

Empirical Formula (Hill Notation):

C₄H₄N₂O₂

CAS Number:

66-22-8

Molecular Weight:

112.09

NACRES:

NA.51

PubChem Substance ID:

24900618

UNSPSC Code:

41106305

EC Number:

200-621-9

MDL number:

MFCD00006016

Beilstein/REAXYS Number:

507828

Product Name

Uracil, ≥99.0%

InChI key

ISAKRJDGNUQOIC-UHFFFAOYSA-N

InChI

1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)

SMILES string

O=C1NC=CC(=O)N1

biological source

synthetic (organic)

assay

≥99.0%

form

powder

mp

>300 °C (lit.)

solubility

1 M NaOH: 50 mg/mL, clear to hazy, colorless to faint yellow or tan

Quality Level

300

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Related Categories

Biochemicals

Nucleosides and Nucleotides

Application

Uracil has been used as:

a nucleotide standard to determine DNA methylation by high-performance liquid chromatography
a component of synthetic define medium for culturing Saccharomyces cerevisiae and its strain
a component of the amino acid supplement to culture Bacillus sp

Biochem/physiol Actions

Uracil and its derivatives play an integral part in medicinal chemistry for the synthesis of cancer, viral infections, autosomal recessive disorder, thyroid, and diabetic drugs.

General description

Uracil belongs to the pyrimidine nucleobase family. It is naturally occurring and is an important and active part of RNA.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Comparative metabolite profiling of wild type and thermo-tolerant mutant of Saccharomyces cerevisiae

Kim S, et al.

Process Biochemistry (Oxford, United Kingdom), 111, 62-68 (2021)

Therapeutic potential of uracil and its derivatives in countering pathogenic and physiological disorders.

Deepthi Ramesh et al.

European journal of medicinal chemistry, 207, 112801-112801 (2020-09-15)

Uracil is one of the most notable pharmacophores in medicinal chemistry as the pyrimidine nucleobase forms an integral part of many commercial drugs. Though the name uracil is usually associated with cancer drugs, there are many uracil-based compounds which can

Environmental and nutritional factors that affect growth and metabolism of the pneumococcal serotype 2 strain D39 and its nonencapsulated derivative strain R6.

Sandra M Carvalho et al.

PloS one, 8(3), e58492-e58492 (2013-03-19)

Links between carbohydrate metabolism and virulence in Streptococcus pneumoniae have been recurrently established. To investigate these links further we developed a chemically defined medium (CDM) and standardized growth conditions that allowed for high growth yields of the related pneumococcal strains

Protection of glucagon-like peptide-1 in cisplatin-induced renal injury elucidates gut-kidney connection.

Daisuke Katagiri et al.

Journal of the American Society of Nephrology : JASN, 24(12), 2034-2043 (2013-10-05)

Accumulating evidence of the beyond-glucose lowering effects of a gut-released hormone, glucagon-like peptide-1 (GLP-1), has been reported in the context of remote organ connections of the cardiovascular system. Specifically, GLP-1 appears to prevent apoptosis, and inhibition of dipeptidyl peptidase-4 (DPP-4)

ABT-450, ritonavir, ombitasvir, and dasabuvir achieves 97% and 100% sustained virologic response with or without ribavirin in treatment-experienced patients with HCV genotype 1b infection.

Pietro Andreone et al.

Gastroenterology, 147(2), 359-365 (2014-05-14)

The interferon-free regimen of ABT-450 (a protease inhibitor), ritonavir, ombitasvir (an NS5A inhibitor), dasabuvir (a non-nucleoside polymerase inhibitor), and ribavirin has shown efficacy in patients with hepatitis C virus (HCV) genotype 1b infection-the most prevalent subgenotype worldwide. We evaluated whether

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