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Merck

1043003

USP

Ascorbic acid

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

L-Ascorbic acid, L-Threoascorbic acid, Antiscorbutic factor, Vitamin C

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About This Item

Empirical Formula (Hill Notation):
C6H8O6
CAS Number:
50-81-7
Molecular Weight:
176.12
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329749065
EC Number:
200-066-2
Beilstein/REAXYS Number:
84272
MDL number:
MFCD00064328

Product Name

Ascorbic acid, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

SMILES string

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

grade

pharmaceutical primary standard

API family

ascorbic acid

form

solid

manufacturer/tradename

USP

technique(s)

HPLC: suitable

mp

190-194 °C (dec.)

application(s)

USP Biologics
pharmaceutical (small molecule)

format

neat

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Application

Ascorbic acid USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Ascorbic Acid Tablets
  • Ascorbic Acid Injection
  • Ascorbic Acid Chewable Gels
  • Ascorbic Acid Compounded Oral Solution
  • Sodium Ascorbate
  • Calcium Ascorbate

General description

Ascorbic acid, commonly known as vitamin C, is a water-soluble vitamin with antioxidant properties. In pharmaceutical and food industries, ascorbic acid is used as an antioxidant to prevent oxidation and spoilage. The USP Ascorbic Acid standard ensures the quality and potency of ascorbic acid in various formulations.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

Other Notes

Sales restrictions may apply.
This product is part of USP Biologics Program.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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W Lee et al.
Clinical chemistry, 28(10), 2165-2169 (1982-10-01)
Measurements of ascorbic acid concentration in leukocytes by "high-performance" liquid chromatography (HPLC) provides better nutritional assessment, leading to better management, particularly of presymptomatic and critically ill patients. This procedure includes a simple, reproducible cell-separation technique that requires no more than
Glutathione
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 41(3), 5054-5054 (2020)
Ascorbic Acid Chewable Gels
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(4), 4765-4765 (2019)
Ascorbic Acid Injection
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 41(6), 383-383 (2022)
Ascorbic Acid Compounded Oral Solution
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(4), 2626-2626 (2020)
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