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203297-M

Bisindolylmaleimide IV

A potent, cell permeable, and selective inhibitor of protein kinase C (IC50 = 87 nM).

Synonym(s):

Bisindolylmaleimide IV, Arcyriarubin A, 2,3- bis(1H-Indol-3-yl)maleimide, Ro 31-6233

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About This Item

Empirical Formula (Hill Notation):
C20H13N3O2
CAS Number:
119139-23-0
Molecular Weight:
327.34
UNSPSC Code:
12352111
MDL number:
MFCD00236432
NACRES:
NA.77
Assay:
≥98% (TLC)
Form:
powder, solid
Quality level:
100
Storage condition:
OK to freeze
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Quality Level

100

assay

≥98% (TLC)

form

powder, solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

dark orange

solubility

methanol: 10 mg/mL

storage temp.

2-8°C

SMILES string

N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([nH]c2)cccc3

InChI

1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)

InChI key

DQYBRTASHMYDJG-UHFFFAOYSA-N

General description

A cell-permeable potent and selective inhibitor of protein kinase C (IC50 = 87 nM) and protein kinase A (IC50 = 2.7 µM).
A potent, cell permeable, and selective inhibitor of protein kinase C (IC50 = 87 nM). Inhibits protein kinase A at much higher concentrations (IC50 = 2.7 µM).

Biochem/physiol Actions

Primary Target
PKC
Target IC50: 87 nM against protein kinase C

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Fabre, S., et al. 1993. Bioorg. Med. Chem.1, 193.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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