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Merck

8.22184

TWEEN® 20

for synthesis

Synonym(s):

Montanox 20, Polyoxyethylene (20) sorbitan monolaurate, Polysorbate 20, Polyethylene glycol sorbitan monolaurate, Polyoxyethylenesorbitan monolaurate

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About This Item

CAS Number:
9005-64-5
NACRES:
NA.22
EC Index Number:
500-018-3
UNSPSC Code:
12352104
MDL number:
MFCD00165986

Key Documents

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vapor pressure

<1.4 hPa ( 20 °C)

form

liquid

potency

38900 mg/kg LD50, oral (Rat)

Quality Level

200

refractive index

n20/D 1.468 (lit.)

pH

6-8 (20 °C, 50 g/L in H2O)

transition temp

flash point 275 °C

storage temp.

2-30°C

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General description

Tween®-20 is a polysorbate-based non-ionic surfactant. It is made up of three chemical units:
  • aliphatic ester chains that hinder biomolecules from nonspecific interactions
  • aliphatic chain that can be non-covalently adsorbed on a hydrophobic surface
  • hydrophilic terminal hydroxyl groups, which can be chemically modified for potential applications.

Application

Non-ionic detergent
Tween®-20 can be used as a structure-directing agent in the preparation of mesoporous oxide films because of its ability to promote textural properties of the films such as controllable crystallinity, film morphology, tailor-designed pore structure, high BET surface area, and controlled film thickness. It is also used in the synthesis of AuNPs/TWEEN/GO composites, where Tween®-20 acts as a reducing and immobilizing agent for AuNPs (Au nanoparticles) as well as a stabilizing agent for GO (graphene oxide).
Tween®-20 can also be used as an emulsifying, solubilizing, and wetting agent in a variety of liquid formulations.

Analysis Note

Density (d 20 °C/ 4 °C): 1.095 - 1.105
Hydroxyl value: 96 - 108
Saponification value: 40 - 50
Identity (IR): passes test
Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.

Legal Information

TWEEN is a registered trademark of Croda International PLC

Storage Class

10 - Combustible liquids

flash_point_f

527.0 °F - Pensky-Martens closed cup

flash_point_c

275 °C - Pensky-Martens closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines
Lo Yu-li
Journal of Controlled Release : Official Journal of the Controlled Release Society, 90(1), 37-48 (2003)
Synthesis, characterization and electrochemical properties of mesoporous zirconia nanomaterials prepared by self-assembling sol-gel method with Tween 20 as a template
Chen Y, et al.
Chemical Engineering Journal, 170(2-3), 518-524 (2011)
Development and evaluation of solid self nano-emulsifying formulation of rosuvastatin calcium for improved bioavailability
Kulkarni NS, et al.
Tropical Journal of Pharmaceutical Research, 14(4), 575-582 (2015)
Mass transport phenomena in oil-in-water emulsions containing surfactant micelles: Ostwald ripening
Weiss J, et al.
Langmuir, 16(17), 6833-6838 (2000)
Hierarchical macro-mesoporous structures in the system TiO2-Al2O3, obtained by hydrothermal synthesis using Tween-20 as a directing agent
Garcia-Benjume ML, et al.
Materials Characterization, 60(12), 1482-1488 (2009)
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