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C5423

Clenbuterol hydrochloride

Name: Clenbuterol hydrochloride
Brand: SIGMA

≥95% (TLC), powder, β2-adrenoceptor agonist

Synonym(s):

4-Amino-α-(t-butylaminomethyl)-3,5-dichlorobenzyl alcohol hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₈Cl₂N₂O · HCl

CAS Number:

21898-19-1

Molecular Weight:

313.65

NACRES:

NA.77

PubChem Substance ID:

24892782

UNSPSC Code:

12352200

EC Number:

244-643-7

MDL number:

MFCD00083280

Assay:

≥95%

Form:

powder

Quality level:

200

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Properties

Product Name

Clenbuterol hydrochloride, ≥95%

Quality Level

200

assay

≥95%

form

powder

drug control

Home Office Schedule 4.2

storage temp.

2-8°C

SMILES string

Cl.CC(C)(C)NCC(O)c1cc(Cl)c(N)c(Cl)c1

InChI

1S/C12H18Cl2N2O.ClH/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7;/h4-5,10,16-17H,6,15H2,1-3H3;1H

InChI key

OPXKTCUYRHXSBK-UHFFFAOYSA-N

Gene Information

human ... ADRB2(154)

Description

Application

Clenbuterol hydrochloride has been used:

as an agonist for β-adrenergic receptor (β-AR) from chick skeletal muscle
to induce hypertrophic effects in masseter, digastric, and temporalis muscles of rat
as a reference β-agonist standard in tandem mass spectrometry(MS-MS)

Biochem/physiol Actions

Clenbuterol hydrochloride is a β2-adrenoceptor agonist and bronchodilator. It is effective in improving peak expiratory flow rate (PEFR) in asthma patients. Clenbuterol is also a performance-enhancing drug as it stimulates the central nervous system and improves oxygen transport. Clenbuterol elicits cardio protective functionality in patients with dilated cardiomyopathy.

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Danger

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Repr. 1B

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Systemic administration of a β2-adrenergic receptor agonist reduces mechanical allodynia and suppresses the immune response to surgery in a rat model of persistent post-incisional hypersensitivity.

Vipin Arora et al.

Molecular pain, 17, 1744806921997206-1744806921997206 (2021-04-09)

Beta 2 adrenergic receptor (β2 AR) activation in the central and peripheral nervous system has been implicated in nociceptive processing in acute and chronic pain settings with anti-inflammatory and anti-allodynic effects of β2-AR mimetics reported in several pain states. In

beta2-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats

Zhang Q, et al.

British Journal of Pharmacology, 160(6), 1561-1572 (2010)

Effects of clenbuterol, a beta2-adrenergic agonist, on sizes of masseter, temporalis, digastric, and tongue muscles

Ishikawa C, et al.

The Open Dentistry Journal, 3, 191-191 (2009)

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