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Merck

M149

Methiothepin mesylate salt

≥98% (HPLC), solid

Synonym(s):

1-[10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt, Metitepine mesylate salt

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About This Item

Linear Formula:
C20H24N2S2 · CH3SO3H
CAS Number:
74611-28-2
Molecular Weight:
452.65
NACRES:
NA.77
PubChem Substance ID:
24278104
UNSPSC Code:
12352200
MDL number:
MFCD00153831
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
desiccated

Key Documents

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InChI key

CZMDZGZYKOGLJY-UHFFFAOYSA-N

SMILES string

CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1

InChI

1S/C20H24N2S2.CH4O3S/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;1-5(2,3)4/h3-8,14,18H,9-13H2,1-2H3;1H3,(H,2,3,4)

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H2O: 13 mg/mL

Quality Level

100

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR6(3362), HTR7(3363)

General description

Methiothepin belongs to a new class of dibenzothiophenes. Methiothepin possesses neuroleptic activity.

Application

Methiothepin mesylate salt has been used to explore the relationship between circulating cells and the niche. It has also been used in serotonin (5-HT) and antagonists in vivo bioassays and in in vivo antagonist and lipopolysaccharide stimulations.

Biochem/physiol Actions

Methiothepin mesylate salt is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000494391
0000494391
0000322135
0000322136
0000329349

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Yuan Lai et al.
Neurobiology of learning and memory, 173, 107278-107278 (2020-07-12)
Conditioned taste aversion (CTA) learning induces the devaluation of a preferred food through its pairing with a stimulus inducing internal illness. In invertebrates, it is still unclear how this aversive learning impairs the memories of stimuli that had been associated
P Schoeffter et al.
British journal of pharmacology, 117(6), 993-994 (1996-03-01)
Human uterine artery smooth muscle cells in culture were shown to express constitutively both 5-ht7 receptor mRNA and 5-ht7-like receptors functionally linked to cyclic AMP formation. 5-Carboxamidotryptamine (5-CT) and 5-HT enhanced forskolin-stimulated cyclic AMP accumulation in these cells, with pEC50
A serotonin receptor (Cg5-HTR-1) mediating immune response in oyster Crassostrea gigas
Jia Y, et al.
Developmental and Comparative Immunology, 82, 83-93 (2018)
Blockade of central 5-hydroxytryptamine receptors by methiothepin
Monachon M A, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 274(2), 192-197 (1972)
F G Boess et al.
Molecular pharmacology, 54(3), 577-583 (1998-09-09)
Ro 63-0563 [4-amino-N-(2,6 bis-methylamino-pyridin-4-yl)-benzene sulfonamide] is a high affinity 5-hydroxytryptamine6 (HT6) receptor antagonist with more than 100-fold selectivity for the 5-HT6 receptor compared with 69 other receptors and binding sites. The present study describes the properties of [3H]Ro 63-0563, the
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Global Trade Item Number

SKUGTIN
MABN177304055977181630

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