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P9623

Paroxetine hydrochloride hemihydrate

≥98% (HPLC), powder, serotonin reuptake inhibitor

Synonym(s):

Paroxetine HCl, (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride hemihydrate

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About This Item

Empirical Formula (Hill Notation):
C19H20FNO3 · HCl · .5 H2O
CAS Number:
110429-35-1
Molecular Weight:
374.83
UNSPSC Code:
12352200
PubChem Substance ID:
24278249
NACRES:
NA.77
MDL number:
MFCD03658863
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Product Name

Paroxetine hydrochloride hemihydrate, ≥98% (HPLC), powder

Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

originator

GlaxoSmithKline

SMILES string

O.Cl[H].Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3

InChI

1S/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/m0../s1

InChI key

QRQSGFFISBKLMZ-YHOFXEKLSA-N

Gene Information

human ... SLC6A4(6532)

Application

Paroxetine hydrochloride hemihydrate has been used: as an antidepressant to study its effects on neural stem cells (NSCs) from embryonic rat hippocampus in vitro; as a CYP 2D6 inhibitor to study its effects on the in vitro production by human recombinant CYP 2D6 of the phenolic metabolites; as an antidepressant to study its effects on the expression of pituitary adenylate cyclase activating polypeptide (PACAP), its receptors and brain-derived neurotrophic factor (BDNF) in rat primary hippocampal neurons

Biochem/physiol Actions

Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant
Selective serotonin reuptake inhibitor; antidepressant
Paroxetine is a phenylpiperidine derivative. It has the ability to cross placenta. Paroxetine is known to increase the risk of congenital cardiac malformations. It might be useful in hormone replacement therapy for treating vasomotor symptoms during menopause. It is known to ameliorate the effects of panic disorder, obsessive‐compulsive disorder and social phobia.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold with the permission of GlaxoSmithKline

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Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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