SML0152
AK-7
≥98% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C19H21BrN2O3S
CAS Number:
Molecular Weight:
437.35
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥15 mg/mL
storage temp.
2-8°C
SMILES string
Brc1cccc(NC(=O)c2cccc(c2)S(=O)(=O)N3CCCCCC3)c1
InChI
1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)
InChI key
IYAYHZZWYNXHEQ-UHFFFAOYSA-N
General description
AK-7 (3-(1-azepanylsulfonyl)-N-(3-bromphenyl) benzamide) is a cell- and brain-permeable, selective SIRT2 (sirtuin 2) inhibitor.
Application
AK-7 has been used in cell culture and cell treatment.
Biochem/physiol Actions
AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.
Selective SIRT2 Inhibitor
Selective SIRT2 Inhibitor AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.
In neurons, the sirtuin 2 inhibitor AK-7 is neuroprotective in vitro and decreases polyglutamine inclusions and cholesterol levels. In mice, treatment with brain-permeable SIRT2 inhibitor AK-7 led to improved motor function, extended survival and decreased brain atrophy. AK-7 decreases the polyglutamine aggregation in R6/2 brain.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7
Wang X,et al.
Drug design, development and therapy (2015)
The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models
Chopra V, et al.
Cell Reports, 2(6), 1492-1497 (2012)
Nagako Sougawa et al.
Transplantation, 103(5), e119-e127 (2019-02-08)
The extracellular matrix, in particular basement membrane components such as laminins (LMs), is essential for stem cell differentiation and self-renewal. LM511 and LM221 are the main extracellular matrix components of the epicardium, where stem cells were abundant. Here, we examined