SML0320
FR180204
≥98% (HPLC), ERK1 and ERK2 inhibitor, powder
Synonym(s):
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine, 5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine, FR 180204
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About This Item
Empirical Formula (Hill Notation):
C18H13N7
CAS Number:
Molecular Weight:
327.34
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
FR180204, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
faintly yellow to dark yellow
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
Nc1n[nH]c2nnc(cc12)-c3c(nn4ccccc34)-c5ccccc5
InChI
1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23)
InChI key
XVECMUKVOMUNLE-UHFFFAOYSA-N
Application
FR180204 has been used as ERK inhibitor:
- to block extracellular-signal-regulated kinase (ERK) in order to validate whether homeobox B7 (HOXB7) regulates the migration and proliferation process via AKT/mitogen-activated protein kinases (MAPK) signaling
- of extracellular-signal-regulated kinase (ERK) to study the effects of signaling pathway inhibitors on differentiation and cell traction stress
- to determine if phosphorylation of this signaling protein is essential for mesenchymal stromal cell (MSC) derived therapeutic efficacy
Biochem/physiol Actions
FR180204 is a potent, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2 (mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2).
FR180204 is a potent, selective, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2.
It can be used to study the roles of ERK as well as for drug development.
Features and Benefits
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Gupta N, et al.
Stem Cells, 36(5), 796-806 (2018)
Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex
Ohori M, et al.
Biochemical and biophysical research communications, 336(1), 357-363 (2005)