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Merck

440140

(3-Aminopropyl)triethoxysilane

99%

Synonym(s):

3-Triethoxysilylpropylamine, APTES, APTS

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About This Item

Linear Formula:
H2N(CH2)3Si(OC2H5)3
CAS Number:
919-30-2
Molecular Weight:
221.37
UNSPSC Code:
12352103
NACRES:
NA.23
PubChem Substance ID:
24867571
EC Number:
213-048-4
Beilstein/REAXYS Number:
1754988
MDL number:
MFCD00008207

Key Documents

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InChI key

WYTZZXDRDKSJID-UHFFFAOYSA-N

InChI

1S/C9H23NO3Si/c1-4-11-14(12-5-2,13-6-3)9-7-8-10/h4-10H2,1-3H3

SMILES string

CCO[Si](CCCN)(OCC)OCC

assay

99%

form

liquid

bp

217 °C/760 mmHg (lit.)

Quality Level

200

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General description

(3-Aminopropyl)triethoxysilane (APTES) is a premium, high-purity aminosilane used to deposit stable Self-Assembled Monolayers (SAMs) on silica, metal oxides, and graphene. Its triethoxy structure allows for slower, more controlled hydrolysis compared to methoxysilanes, facilitating the formation of uniform, reproducible molecular layers. Critically for life science research, APTES releases ethanol rather than methanol during silanization, making it the preferred reagent for functionalizing surfaces intended for live-cell interfaces and clinical diagnostics. This 97% assay grade is optimized to provide a high density of reactive methoxy groups, ensuring rapid, robust silanization for applications where maximum surface coverage and strong covalent anchoring are required in short reaction windows.

Application

As a biocompatible molecular bridge, APTES is essential for engineering intelligent interfaces and stimuli-responsive systems that enable precise interactions at the intersection of nanotechnology, biology, and electronics.


• Biocompatible Drug Delivery: Preferred for coating Mesoporous Silica Nanoparticles (MSNs) and magnetic nanocarriers intended for in vivo use, ensuring minimal cytotoxicity during the functionalization process.


• Advanced Histology & Imaging: Used to prepare positively charged microscope slides that enhance the adhesion of tissue sections and cells for complex immunohistochemical (IHC) and in situ hybridization (ISH) procedures.


• Nano-Biosensors: Facilitates the immobilization of DNA and proteins onto graphene-based field-effect transistors (GFETs) and fiber-optic sensors for ultra-sensitive pathogen and biomarker detection.


• Regenerative Medicine: Surface-modifies hollow microcarriers (HMCs) and 3D-scaffolds to promote cell attachment and proliferation in tissue engineering and biopharmaceutical production.


• Organic Electronics (OFETs): Serves as an interfacial modifier to improve the electrical contact between graphene flakes and metal electrodes, as well as passivating gate dielectrics in flexible electronic devices.


• Gene Vector Engineering: Enables the synthesis of monodispersed, soluble DNA-nanodiamond conjugates and other cationic vectors for non-viral gene transfection.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 1

flash_point_f

199.4 °F - closed cup

flash_point_c

93 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ6531
MKCX9776
MKCX7323
MKCX3692
WXBF3340V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the viscosity of Product 440140, APTES (3-Aminopropyl)triethoxysilane)?

    According to our supplier’s information the viscosity is 1.6 cS.

  4. What is Product 440140, APTES (3-Aminopropyl)triethoxysilane) soluble in?

    This product is soluble in water.

  5. How should Product 440140, APTES (3-Aminopropyl)triethoxysilane) be stored?

    We would recommend storing this product in accordance with our MSDS, which recommends storing at room temperature and under inert gas since this product is moisture sensitive.

  6. What is the refractive index of Product 440140, APTES (3-Aminopropyl)triethoxysilane)?

    According to our supplier the refractive index is 1.420.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

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    Ask a Scientist here.

Functionalisation of Detonation Nanodiamond for Monodispersed, Soluble DNA-Nanodiamond Conjugates Using Mixed Silane Bead-Assisted Sonication Disintegration.
Edgington, et al.
Scientific Reports, 8(1), 728-728 (2018)
Polymer International, 55, 1277-1277 (2006)
Hollow microcarriers for large-scale expansion of anchorage-dependent cells in a stirred bioreactor.
YekrangSafakar, et al.
Biotechnology and Bioengineering, 115(7), 1717-1728 (2018)
Platinum nanoparticles homogenously decorating multilayered reduced graphene oxide for electrical nanobiosensor applications.
Proa-Coronado, et al.
Thin Solid Films, 658(1), 54-60 (2018)
Effect of divalent versus monovalent cations on the MS2 retention capacity of amino-functionalized ceramic filters.
Bartels J, et al.
Physical Chemistry Chemical Physics, 20(16), 11215-11223 (2018)
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