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907251

H-L-Photo-lysine HCl

≥98%

Synonym(s):

(S)-2-Amino-6-((2-(3-methyl-3H-diazirin-3-yl)ethoxy)carbonylamino)hexanoic acid hydrochloride, (S)-2-Amino-6-((2-(3H-diazirin-3-yl)propoxy)carbonylamino)hexanoic acid hydrochloride, 3′-Azibutyl-N-carbamoyl-lysine hydrochloride, Abk, Diazirine amino acid, Photo-Lys, Photo-crosslinking amino acid, Photoprobe building block

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About This Item

Empirical Formula (Hill Notation):
C11H21ClN4O4
CAS Number:
2421187-79-1
Molecular Weight:
308.76
MDL number:
MFCD28133397
UNSPSC Code:
12352209
NACRES:
NA.26
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assay

≥98%

form

powder

reaction suitability

reaction type: solution phase peptide synthesis

availability

available only in USA

application(s)

peptide synthesis

storage temp.

−20°C

SMILES string

N[C@@H](CCCCNC(=O)OCCC1(N=N1)C)C(=O)O

InChI

1S/C11H20N4O4/c1-11(14-15-11)5-7-19-10(18)13-6-3-2-4-8(12)9(16)17/h8H,2-7,12H2,1H3,(H,13,18)(H,16,17)/t8-/m0/s1

InChI key

LUCMNTLJAFTFDU-QMMMGPOBSA-N

Application

H-L-Photo-lysine HCl is a diazirine-containing lysine amino acid and multifunctional probe building blocks. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (~360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907383.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Other Notes

A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation

Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking</A

Genetic code expansion for multiprotein complex engineering

Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells

Probing Protein-Protein Interactions with a Genetically Encoded Photo-crosslinking Amino Acid

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

4.1B - Flammable solid hazardous materials

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX8725

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