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860629P

Avanti

C24:1 Dihydroceramide (d18:0/24:1(15Z))

Avanti Research™ - A Croda Brand

Synonym(s):

N-nervonoyl-D-erythro-sphinganine

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About This Item

Empirical Formula (Hill Notation):
C42H83NO3
CAS Number:
352518-80-0
Molecular Weight:
650.11
MDL number:
MFCD02259305
UNSPSC Code:
12352211
NACRES:
NA.25
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Product Name

C24:1 Dihydroceramide (d18:0/24:1(15Z)), Avanti Research™ - A Croda Brand 860629P, powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (860629P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860629P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC[C@]([H])(NC(CCCCCCCCCCCCC/C=C\CCCCCCCC)=O)[C@]([H])(O)CCCCCCCCCCCCCCC

InChI

1S/C42H83NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-42(46)43-40(39-44)41(45)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h17-18,40-41,44-45H,3-16,19-39H2,1-2H3,(H,43,46)/b18-17-/t40-,41+/m0/s1

InChI key

YUULKFVZRXQHPM-ATHUGRIKSA-N

Application

C24:1 Dihydroceramide has been used as a standard in quadrupole time-of-flight (Q-TOF) mass spectrometry for the measurement of sphingolipid metabolites in adipose tissue. It has also been used a standard in diacylglycerol kinase (DGK) assay to quantify dihydroceramides in CLN9-deficient cells.

Biochem/physiol Actions

C24:1 Dihydroceramide is a synthetic dihydroceramide. Dihydroceramides are reduced to ceramides by the enzyme dihydroceramide desaturase. Elevated levels of serum 24:1 DHC has been observed in patients with history of hepatocellular carcinoma (HCC) pre-orthopic liver transplantation (OLT), compared to patients with no prior HCC. Therefore, 24:1 DHC can be used as a HCC biomarker in post-OLT patients.

Packaging

5 mL Amber Glass Screw Cap Vial (860629P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

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C22: 0-and C24: 0-dihydroceramides confer mixed cytotoxicity in T-cell acute lymphoblastic leukemia cell lines
Holliday Jr, et al.
Testing, 8(9) (2013)
Michael W Holliday et al.
PloS one, 8(9), e74768-e74768 (2013-09-17)
We previously reported that fenretinide (4-HPR) was cytotoxic to acute lymphoblastic leukemia (ALL) cell lines in vitro in association with increased levels of de novo synthesized dihydroceramides, the immediate precursors of ceramides. However, the cytotoxic potentials of native dihydroceramides have
C22: 0-and C24: 0-dihydroceramides confer mixed cytotoxicity in T-cell acute lymphoblastic leukemia cell lines
Holliday Jr, et al.
PLoS ONE, 8(9) (2013)
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