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About This Item
Empirical Formula (Hill Notation):
C32H65NO3
CAS Number:
Molecular Weight:
511.86
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
C14 dihydroceramide (d18:0/14:0), Avanti Research™ - A Croda Brand 860632P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860632P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860632P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
OC[C@]([H])(NC(CCCCCCCCCCCCC)=O)[C@]([H])(O)CCCCCCCCCCCCCCC
InChI
1S/C32H65NO3/c1-3-5-7-9-11-13-15-16-18-19-21-23-25-27-31(35)30(29-34)33-32(36)28-26-24-22-20-17-14-12-10-8-6-4-2/h30-31,34-35H,3-29H2,1-2H3,(H,33,36)/t30-,31+/m0/s1
InChI key
UDTSZXVRDXQARY-IOWSJCHKSA-N
General description
C14 dihydroceramide is a synthetic dihydroceramide. Acylation of sphinganine with myristoyl (FA-CoA with C14 acyl chain) by dihydro ceramide synthase 1, yields C14-dihydroceramide.
Application
C14 dihydroceramide has been used as a standard for measuring the concentration of sphingolipid metabolites in adipose tissues by quadrupole time-of-flight (Q-TOF) mass spectrometry.
Packaging
5 mL Amber Glass Screw Cap Vial (860632P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
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Erwan Beauchamp et al.
Biochimie, 89(12), 1553-1561 (2007-08-25)
Dihydroceramide Delta4-desaturase (DES) catalyzes the desaturation of dihydroceramide into ceramide. In mammals, two gene isoforms named DES1 and DES2 have recently been identified. The regulation of these enzymes is still poorly understood. This study was designed to examine the possible
Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism
Mullen TD, et al.
Journal of Lipid Research, 52(1), 68-77 (2011)
Myristic acid increases the activity of dihydroceramide Delta4-desaturase 1 through its N-terminal myristoylation
Beauchamp E, et al.
Biochimie, 89(12), 1553-1561 (2007)