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D8189

Bis(1,3-dibutylbarbituric acid) trimethine oxonol

≥95% purity (HPLC), powder or solid

Synonym(s):

DiBAC4(3)

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About This Item

Empirical Formula (Hill Notation):
C27H40N4O6
CAS Number:
70363-83-6
Molecular Weight:
516.63
UNSPSC Code:
12171500
PubChem Substance ID:
329798857
NACRES:
NA.47
MDL number:
MFCD07437857
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Product Name

Bis(1,3-dibutylbarbituric acid) trimethine oxonol, ≥95% (HPLC)

Quality Level

100

assay

≥95% (HPLC)

form

powder or solid

technique(s)

titration: suitable

color

orange to dark red

solubility

DMF: soluble, DMSO: soluble

ε (extinction coefficient)

≥90000 at 490-496 nm in methanol

fluorescence

λex 513-519 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

2-8°C

SMILES string

CCCCN(C(N(CCCC)C1=O)=O)C(C1=C/C=C/C2C(N(CCCC)C(N(CCCC)C2=O)=O)=O)=O

InChI

1S/C27H40N4O6/c1-5-9-16-28-22(32)20(23(33)29(26(28)36)17-10-6-2)14-13-15-21-24(34)30(18-11-7-3)27(37)31(25(21)35)19-12-8-4/h13-15,20H,5-12,16-19H2,1-4H3/b14-13+

InChI key

ATJCYSYHWGQAET-BUHFOSPRSA-N

Application

Application in high throughput screening.
Bis(1,3-dibutylbarbituric acid) trimethine oxonol has been used for monitoring changes in the plasma membrane potential. It also has applications in high throughput screening.

Biochem/physiol Actions

Bis(1,3-dibutylbarbituric acid) trimethine oxonolis a translational membrane potential dye that is redistributed in the cell as membrane potential changes.
Translational membrane potential dye that is redistributed in the cell as membrane potential changes.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKDB0541
MKCX4524
MKCV5935
MKCT9973
MKCS9018

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B Lee et al.
Journal of applied microbiology, 127(3), 701-712 (2019-06-20)
Metal nanoparticles are promising materials for the management of infectious diseases as known to have various antimicrobial activities in pathogenic micro-organisms. Among them, gold nanoparticles (AuNPs) are used in a wide range of fields such as photodynamic therapy, molecular diagnostics
T Bräuner et al.
Biochimica et biophysica acta, 771(2), 208-216 (1984-04-11)
The usefulness of a new voltage-sensitive fluorescent dye, the membrane permeant negatively charged oxonol dye diBA-C4-(3)-, was evaluated by measuring the membrane potentials of BICR/M1R-k and L cells with glass microelectrodes and simultaneously recording the fluorescence of the stained cells.
Michael Fruci et al.
PloS one, 13(10), e0205036-e0205036 (2018-10-06)
Exposure of P. aeruginosa to the aminoglycoside (AG) paromomycin (PAR) induced expression of the PA3720-armR locus and the mexAB-oprM multidrug efflux operon that AmgR controls, although PAR induction of mexAB-oprM was independent of armR. Multiple AGs promoted mexAB-oprM expression and
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