C3045
Cholesterol
powder, BioReagent, suitable for cell culture, ≥99%
Synonym(s):
3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol
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About This Item
biological source
ovine wool
Quality Segment
product line
BioReagent
assay
≥99%
form
powder
technique(s)
cell culture | mammalian: suitable
bp
360 °C (lit.)
mp
147-149 °C (lit.)
solubility
H2O: 0.002 mg/mL, Tween: soluble, ethanol: soluble, serum: soluble
density
1.067 g/mL at 25 °C (lit.)
shipped in
ambient
storage temp.
−20°C
SMILES string
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI key
HVYWMOMLDIMFJA-DPAQBDIFSA-N
Gene Information
human ... POLA1(5422), TOP2A(7153)
rat ... Ar(24208), Polb(29240)
General description
Cholesterol, a major sterol is the precursor for steroid hormones, bile acid and vitamin in mammals and coordinates endocytosis. It complexes with protein to form lipoproteins for transport in blood. It exists either as high-density lipoprotein (HDL) or low-density lipoprotein (LDL). HDL also called good cholesterol has less lipid content. LDL or bad cholesterol has high lipid content. Statin inhibition of HMG-CoA reductase enzyme in the cholesterol biosynthesis pathway controls elevated cholesterol levels in atherosclerosis and hypercholesterolemia. Low levels of cholesterol results in hypothyroidism, familial hypobetalipoproteinemia and liver disease. Imbalance of cholesterol homeostasis and intracellular cholesterol levels play a key role in cancer development. High cholesterol levels favor breast cancer progression.
Application
- as a medium supplement in chorionic villous tissue culture form placenta
- as a component of hormone pellet for implantation in mice ovary
- for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1
Biochem/physiol Actions
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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