H3281
Hematin porcine
Synonym(s):
Ferrihemate, Hematin porcine
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About This Item
Linear Formula:
C34H33N4O5Fe
CAS Number:
Molecular Weight:
633.49
NACRES:
NA.61
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
239-518-9
MDL number:
Form:
powder
Biological source:
Porcine
biological source
Porcine
Quality Level
form
powder
storage temp.
2-8°C
SMILES string
Cc1c(CCC(O)=O)c2cc3c(CCC(O)=O)c(C)c4cc5nc(cc6c(C=C)c(C)c(cc1n2)n6[Fe](O)n34)c(C)c5C=C
InChI
1S/C34H34N4O4.Fe.H2O/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);;1H2/q;+3;/p-3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;
InChI key
BMUDPLZKKRQECS-HXFTUNQESA-K
Gene Information
pig ... MCOLOR(100530327)
Application
Hematin was used in a study to test in vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. It was also used in a study to test in-vitro bacterial identification using fluorescence spectroscopy with an optical fiber system.
Hematin porcine has been used as a:
- polymerase chain reaction (PCR) inhibitor to evaluate its effect on the PowerQuant System used for detecting degraded DNA in samples
- supplement in Haemophilus test medium to culture Haemophilus influenzae isolates for resistance studies
- standard to determine the heme coefficient as a part of heme iron analysis using raw beef lung
Biochem/physiol Actions
Hematin is a hydroxide of heme. It may be used to treat acute porphyric attacks. Hematin suppresses the hepatic aminolevulinic acid (ALA) function and replenishes cytochrome action by restoring the endogenous heme deficit. Early administration of hematin can prevent irreversible neuronal damage induced due to metabolic disorders.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Peter Bergman et al.
PloS one, 6(8), e24394-e24394 (2011-09-14)
Statin treatment has been associated with a beneficial outcome on respiratory tract infections. In addition, previous in vitro and in vivo experiments have indicated favorable effects of statins in bacterial infections. The aim of the present study was to elucidate
Muriel Vayssier-Taussat et al.
PLoS pathogens, 6(6), e1000946-e1000946 (2010-06-16)
Bacterial pathogens typically infect only a limited range of hosts; however, the genetic mechanisms governing host-specificity are poorly understood. The alpha-proteobacterial genus Bartonella comprises 21 species that cause host-specific intraerythrocytic bacteremia as hallmark of infection in their respective mammalian reservoirs
Effect of drying temperature on nutritional, functional and pasting propertiesand storage stability of beef lung powder, a prospective protein ingredient for food supplements
Jayawardena S, et al.
LWT--Food Science and Technology, 113315-113315 (2022)