SML2912
UNC4976 Trifluoroacetate
≥95% (HPLC)
Synonym(s):
Methyl N6-(bicyclo[2.2.1]heptan-2-yl)-N2-(4-(tert-butyl)benzoyl)-L-phenylalanyl-L-alanyl-L-leucyl-N6-methyl-L-lysyl-L-serinate trifluoroacetate
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About This Item
Empirical Formula (Hill Notation):
C47H70N6O8 · xC2HF3O2
Molecular Weight:
847.09 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
N([C@@H](CO)C(=O)OC)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)c4ccc(cc4)C(C)(C)C)Cc3ccccc3)C)CC(C)C)CCCCN(C1C2CC(C1)CC2)C
InChI key
UKWNWTBRKZUHGX-GKUWNYOMSA-N
assay
≥95% (HPLC)
form
film
color
white to beige
shipped in
wet ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
UNC4976 is a cell penetrant and potent positive allosteric modulator (PAM) of CBX7 chromodomain of polycomb repressive complex 1 that enhances CBX7 chromodomain affinity for nucleic acids. UNC4976 substantially potentiates the expression of polycomb target genes.
cell penetrant and potent positive allosteric modulator (PAM) of CBX7 chromodomain
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Kelsey N Lamb et al.
Cell chemical biology, 26(10), 1365-1379 (2019-08-20)
Polycomb-directed repression of gene expression is frequently misregulated in human diseases. A quantitative and target-specific cellular assay was utilized to discover the first potent positive allosteric modulator (PAM) peptidomimetic, UNC4976, of nucleic acid binding by CBX7, a chromodomain methyl-lysine reader
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