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115500 Adenophostin A, Hexasodium Salt - Calbiochem

115500
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₆H₂₀N₅O₁₈P₃ · 6Na

Products

Catalogue NumberPackaging Qty/Pack
115500-50UG 50 μg
Description
OverviewOne of the most potent known agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R; EC50 = 10.9 nM). Exhibits about 50- to 100-fold greater affinity for IP3R than IP3. Stimulates Ca2+ release from Ins(1,4,5)P3-sensitive Ca2+ stores in microsomal preparations, permeabilized cells, and lipid vesicles containing purified InsP3R (EC50 = 14.7 nM for Ca2+ release from permeabilized hepatocytes). Does not bind to Ins(1,3,4,5)P4 binding sites and is resistant to enzymatic degradation.
Catalogue Number115500
Brand Family Calbiochem®
References
ReferencesCorrea, V., et al. 2001. Mol. Pharmacol. 59, 1206.
Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
Hirota, J., et al. 1995. FEBS Lett. 368, 248.
Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₆H₂₀N₅O₁₈P₃ · 6Na
Chemical formulaC₁₆H₂₀N₅O₁₈P₃ · 6Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationAdenophostin A, Hexasodium Salt, is a potent agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R; EC50 = 10.9 nM). Exhibits about 50- to 100-fold greater affinity for IP3R than IP3.
Biological Information
Primary TargetType 1 inositol 1,4,5-trisphosphate receptor (InsP3R)
Primary Target IC<sub>50</sub>EC50 = 10.9 nM against InsP3R
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Adenophostin A, Hexasodium Salt - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Adenophostin A, Hexasodium Salt - Calbiochem Certificates of Analysis

TitleLot Number
115500

References

Reference overview
Correa, V., et al. 2001. Mol. Pharmacol. 59, 1206.
Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
Hirota, J., et al. 1995. FEBS Lett. 368, 248.
Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
DescriptionA glyconucleotide originally isolated from the culture broth of Penicillium brevicompactum. Adenophostin A is the most potent known agonist of type 1 inositol 1,4,5-trisphosphate receptor (InsP3R). Exhibits about 50-100 fold greater affinity for the InsP3R than IP3. Stimulates Ca2+ release from Ins(1,4,5)P3-sensitive Ca2+ stores in microsomal preparations, permeabilized cells, and lipid vesicles containing purified InsP3R. Does not bind to Ins(1,3,4,5)P4 binding sites and is resistant to degradation by the enzymes that metabolize (1,4,5)InsP3.
FormWhite solid
Chemical formulaC₁₆H₂₀N₅O₁₈P₃ · 6Na
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityH₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesCorrea, V., et al. 2001. Mol. Pharmacol. 59, 1206.
Marchant, J.S., and Taylor, C.W. 1998. Biochemistry 37, 11524.
DeLisle, S., et al. 1997. J. Biol. Chem. 272, 9956.
Hartzell, H.C., et al. 1997. Mol. Pharmacol. 51, 683.
Marchant, J.S., et al. 1997. Biochemistry 36, 12780.
Hirota, J., et al. 1995. FEBS Lett. 368, 248.
Takahashi, M., et al. 1994. J. Biol. Chem. 269, 369.

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Accessories (Secondary)

Catalogue Number Description
100801 Label set acc. GHS
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Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Calcium Signaling > IP3 and Ryanodine Channel Modulators