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344931 Furin Inhibitor II - Calbiochem

344931
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₆H₇₅N₂₅O₆

Products

Catalogue NumberPackaging Qty/Pack
344931-1MG Plastic ampoule 1 mg
Description
OverviewA polyarginine compound that acts as a potent, specific, and competitive inhibitor of furin (Ki = 106 nM). Inhibits Subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (Ki = 580 nM and 13 µM, respectively). Has a stimulatory effect on the activity of prohormone convertase 2 (PC2). The D-peptides are suggested to be more resistant to in vivo hydrolysis than L-peptides.
Catalogue Number344931
Brand Family Calbiochem®
SynonymsHexa-D-arginine, H-(D)RRRRRR-NH₂
References
ReferencesCameron, A., et al. 2000. J. Biol. Chem. 275, 36741.
Product Information
ATP CompetitiveY
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₃₆H₇₅N₂₅O₆
Chemical formulaC₃₆H₇₅N₂₅O₆
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary Targetfurin
Primary Target K<sub>i</sub>106 nM against Furin
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-(D)Arg-Arg-Arg-Arg-Arg-Arg-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Furin Inhibitor II - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Furin Inhibitor II - Calbiochem Certificates of Analysis

TitleLot Number
344931

References

Reference overview
Cameron, A., et al. 2000. J. Biol. Chem. 275, 36741.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2008 RFH
SynonymsHexa-D-arginine, H-(D)RRRRRR-NH₂
DescriptionA polyarginine that acts as a potent, specific, and competitive inhibitor of furin (Ki = 106 nM). Inhibits subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (Ki = 580 nM and 13 µM, respectively). Does not affect the activity of PC2. The D-peptides are suggested to be more resistant to in vivo hydrolysis than the L-peptides.
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₆H₇₅N₂₅O₆
Peptide SequenceH-(D)Arg-Arg-Arg-Arg-Arg-Arg-NH₂
Purity≥95% by HPLC
SolubilityDMSO or H₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCameron, A., et al. 2000. J. Biol. Chem. 275, 36741.