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401478 IκB Kinase Inactive Control Peptide, Cell-Permeable - Calbiochem

401478
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₃₈H₂₂₉N₃₇O₄₃S

Products

Catalogue NumberPackaging Qty/Pack
401478-1MG Plastic ampoule 1 mg
Description
OverviewAn inactive control for IκB Kinase Inhibitor Peptide (Cat. No. 401477). A 14-amino acid peptide corresponding to the mutated recognition sequence of IκB (Ser32→Ala and Ser36→Ala) fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Does not have any inhibitory effect on LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells at 50 µg/ml.
Catalogue Number401478
Brand Family Calbiochem®
SynonymsAc-AAVALLPAVLLALLAPDDRHDAGLDAMKDE-NH₂
References
ReferencesSwaroop, N., et al. 2001. Pharm. Res. 18, 1631.
Traenckner, E.B., et al. 1995. EMBO J. 14, 2876.
Product Information
ATP CompetitiveN
FormOff-white to white solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₃₈H₂₂₉N₃₇O₄₃S
Chemical formulaC₁₃₈H₂₂₉N₃₇O₄₃S
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetAn inactive control for IκB Kinase Inhibitor Peptide
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ala-Gly-Leu-Asp-Ala-Met-Lys-Asp-Glu-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

IκB Kinase Inactive Control Peptide, Cell-Permeable - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

IκB Kinase Inactive Control Peptide, Cell-Permeable - Calbiochem Certificates of Analysis

TitleLot Number
401478

References

Reference overview
Swaroop, N., et al. 2001. Pharm. Res. 18, 1631.
Traenckner, E.B., et al. 1995. EMBO J. 14, 2876.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-July-2014 JSW
SynonymsAc-AAVALLPAVLLALLAPDDRHDAGLDAMKDE-NH₂
DescriptionAn inactive control for IkB Kinase Inhibitor Peptide (Cat. No. 401477). A 14-amino acid peptide corresponding to the mutated recognition sequence of IkB (Ser32 → Ala and Ser36 → Ala), linked to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Does not have any inhibitory effect on LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells at 50 µg/ml.
FormOff-white to white solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₃₈H₂₂₉N₃₇O₄₃S
Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ala-Gly-Leu-Asp-Ala-Met-Lys-Asp-Glu-NH₂
Purity≥97% by HPLC
SolubilityH₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSwaroop, N., et al. 2001. Pharm. Res. 18, 1631.
Traenckner, E.B., et al. 1995. EMBO J. 14, 2876.