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412510 IRE1 Inhibitor I, STF-083010 - Calbiochem

412510
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₅H₁₁NO₃S₂

Products

Catalogue NumberPackaging Qty/Pack
412510-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable salicylidene compound that is shown to directly target Ireα1 and disrupt Ire1-XBP1 (X-box binding protein) unfolded protein response (UPR) pathway in RPMI8226 multiple myeloma (MM) cells. Selectively inhibits ER stress-initiated endonuclease activity of Ire1 and blocks XPB1 mRNA splicing in MM cells at 60 µM and XBP1 activity in transgenic XBP1-luc mice (bortezomib 1mg/kg and 60 mg/kg of STF-083010, i.p.). Displays preferential cytotoxicity towards CD138+ cells over B, T and NK cells and antitumor properties.
Catalogue Number412510
Brand Family Calbiochem®
SynonymsER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010, N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide
References
ReferencesLerner, A.G., et al. 2012 Cell Metabolism 16, 250.
Papandreou, I., et al. 2010. Blood 117, )1311.
Product Information
FormYellow powder
Hill FormulaC₁₅H₁₁NO₃S₂
Chemical formulaC₁₅H₁₁NO₃S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationIRE1 Inhibitor I, STF-083010, CAS 307543-71-1, is a cell-permeable compound that directly targets Ireα1 and disrupt Ire1-XBP1 unfolded protein response pathway in RPMI8226 multiple myeloma cells.
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

IRE1 Inhibitor I, STF-083010 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

IRE1 Inhibitor I, STF-083010 - Calbiochem Certificates of Analysis

TitleLot Number
412510

References

Reference overview
Lerner, A.G., et al. 2012 Cell Metabolism 16, 250.
Papandreou, I., et al. 2010. Blood 117, )1311.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-April-2012 JSW
SynonymsER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010, N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide
DescriptionA cell-permeable salicylidene compound that is shown to directly target Ireα1 and disrupt Ire1-XBP1 (X-box binding protein) unfolded protein response (UPR) pathway in RPMI8226 multiple myeloma (MM) cells. Selectively inhibits ER stress-initiated endonuclease activity of Ire1 and blocks XPB1 mRNA splicing in MM cells at 60 µM and XBP1 activity in transgenic XBP1-luc mice (bortezomib 1mg/kg and 60 mg/kg of STF-083010, i.p.). Displays preferential cytotoxicity towards CD138+ cells over B, T and NK cells and antitumor properties.
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₅H₁₁NO₃S₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml; clear, yellow solution)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Toxicity Regulatory Review
ReferencesLerner, A.G., et al. 2012 Cell Metabolism 16, 250.
Papandreou, I., et al. 2010. Blood 117, )1311.