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Merck

861340

Thionin acetate salt

certified by the BSC, Dye content ≥85 %

Synonym(s):

3,7-Diamino-5-phenothiazinium acetate, Lauth’s violet

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About This Item

Empirical Formula (Hill Notation):
C12H9N3S · C2H4O2
CAS Number:
78338-22-4
Molecular Weight:
287.34
PubChem Substance ID:
24888537
UNSPSC Code:
12171500
NACRES:
NA.47
MDL number:
MFCD00081194
Colour Index Number:
52000
Beilstein/REAXYS Number:
4345073

Key Documents

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SMILES string

CC([O-])=O.Nc1ccc2nc3ccc(N)cc3[s+]c2c1

InChI

1S/C12H10N3S.C2H4O2/c13-7-1-3-9-11(5-7)16-12-6-8(14)2-4-10(12)15-9;1-2(3)4/h1-6H,13-14H2;1H3,(H,3,4)/q+1;/p-1

InChI key

OWXBIRAFHWASMS-UHFFFAOYSA-M

agency

certified by the BSC

form

powder

composition

Dye content, ≥85%

technique(s)

microbe id | staining: suitable

λmax

598 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

200

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General description

Thionin is a diaminothiazine, metachromatic cationic dye.

Application

Thionin is widely used as a biological stain, especially in histology. It has been used in the Nissl stain for the labeling of neuronal cell bodies.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SHBT4045
SHBT4046
SHBR2794
SHBN8564
MKCM9285

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Cerebellar Purkinje cell neurodegeneration after cardiac arrest: effect of therapeutic hypothermia.
Paine MG, et al.
Resuscitation, 83, 1511-1511 (2012)
Contribution of carbohydrate histochemistry to glycobiology.
Danguy A, et al.
Histology and Histopathology, 9, 155-155 (1994)
Yunying Xie et al.
Analytica chimica acta, 699(1), 44-48 (2011-06-28)
We reported a graphene-based immunosensor for electrochemical quantification of phosphorylated p53 on serine 15 (phospho-p53(15)), a potential biomarker of gamma-radiation exposure. The principle is based on sandwich immunoassay and the resulting immunocomplex is formed among phospho-p53 capture antibody, phospho-p53(15) antigen
Shenguang Ge et al.
The Analyst, 137(19), 4440-4447 (2012-08-07)
This paper describes a novel electrochemical immunosensor using a nanoporous gold (NPG)/graphene (GN) hybrid platform combined with horseradish peroxidase (HRP)-encapsulated liposomes as labels for the sensitive detection of cancer antigen 15-3 (CA 15-3). The electrochemical detection was based on the
Zhao Zhang et al.
The Analyst, 138(18), 5365-5370 (2013-07-24)
A novel protocol of electrochemical thrombin aptasensor based on a goldnanoparticles/thionine-graphene (AuNPs/Th-G) nanocomposite modified glassy carbon electrode was presented. Graphene was non-covalently functionalized by thionine viaπ-stacking interaction, and then AuNPs were electrodeposited onto the Th-G surface. The morphology and conductivity
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