M6908
Myeloperoxidase from human leukocytes
lyophilized powder, ≥50 units/mg protein
Synonym(s):
MPO, Peroxidase, myelo
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About This Item
CAS Number:
NACRES:
NA.32
UNSPSC Code:
12352200
MDL number:
InChI
1S/H2O3/c1-3-2/h1-2H
SMILES string
[O+H2]O[O-]
InChI key
JSPLKZUTYZBBKA-UHFFFAOYSA-N
biological source
human leucocytes
form
lyophilized powder
specific activity
≥50 units/mg protein
solubility
H2O: soluble, aqueous buffers such as 50 mM sodium acetate: soluble (Freezing of the enzyme in solution may result in a substantial loss of activity.)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
human ... MPO(4353)
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Analysis Note
Source material tested and found negative for antibody to HIV and for HBSAG.
Application
Myeloperoxidase (MPO) from human leukocytes has been used in MPO assay.
Myeloperoxidase from human leukocytes has been used:
- as a standard to quantify the neutrophil (polymorphonuclear cell [PMN]) infiltration in lung tissue
- as a neutrophil extracelullar trap (NET) component to stimulate 106 dendritic cells or 106 macrophages
- as a standard in myeloperoxidase (MPO) assay to measure pancreatic MPO
Biochem/physiol Actions
Myeloperoxidase (MPO) has a crucial role to play in destruction of various microorganisms and foreign cells, such as bacteria, fungi, viruses, red cells and malignant and nonmalignant nucleated cells. MPO catalyzes the production of number of reactive oxidant species (ROS) that influence tissue damage during inflammation. MPO and its downstream inflammatory pathways function as a potent therapeutic target for prophylaxis of atherosclerotic cardiovascular disease. MPO catalyze the synthesis of polychlorinated dibenzo(p)dioxins and furans (PCDD/F) from precursor such as chlorophenols in presence of hydrogen peroxide (H2O2).
General description
Myeloperoxidase (MPO) is encoded by the gene mapped to human chromosome 17q22-24. The encoded protein is a leukocyte-derived enzyme and is an integral constituent of the innate immune response. MPO belongs to the heme peroxidase superfamily. MPO is a heme protein containing iron and is highly expressed in leukocytes, neutrophils, monocytes and some subtypes of tissue macrophages.
Other Notes
Lysosomal heme-containing protein.
One unit of myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25 °C
Physical form
Lyophilized from 50 mM sodium acetate buffer, pH 6.0, 0.1 M sodium chloride
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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The localization of the human myeloperoxidase gene is in close proximity to the translocation breakpoint in acute promyelocytic leukemia.
Chang KS
Leukemia, 1(15), 458-462 (1987)
Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
Romac JMJ, et al.
Nature Communications, 9(1715), 1-10 (2018)
Cytokine kinetics and other host factors in response to pneumococcal pulmonary infection in mice.
Bergeron Y
Infection and Immunity, 66(3), 912-922 (1998)
Clinical manifestation of myeloperoxidase deficiency.
Lanza F
Journal of Molecular Medicine, 76(10), 676-681 (1998)
Sharbel Weidner Maluf et al.
Genetics and molecular biology, 43(2), e20180390-e20180390 (2020-06-20)
The objective of this study was to evaluate the level of genomic instability in patients with celiac disease and to establish a relationship between inflammation, oxidative stress, and DNA damage in these patients. Myeloperoxidase (MPO) activity, adenosine deaminase, nitric oxide
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