O2751
Sodium oxamate
≥98%
Synonym(s):
Aminooxoacetic acid sodium salt, Oxalic acid monoamide sodium salt, Oxamic acid sodium salt
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About This Item
Linear Formula:
NH2COCOONa
CAS Number:
Molecular Weight:
111.03
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
EC Number:
209-290-5
Beilstein/REAXYS Number:
6538153
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥98%
form
powder
mp
300 °C
solubility
water: 50 mg/mL, clear, colorless
SMILES string
[Na+].NC(=O)C([O-])=O
InChI
1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1
InChI key
RQVZIJIQDCGIKI-UHFFFAOYSA-M
Application
Sodium oxamate has been used:
- as one of the variable in flow injection analysis
- in in vitro angiogenesis assay
- to confirm the stimulatory role of stearic acid on lactate dehydrogenase mediated lactate production
Biochem/physiol Actions
Sodium oxamate influences the fatty acid metabolism. It might be useful for the treatment of diabetes.
Structural analog of pyruvate, inhibits L(+)-lactate dehydrogenase and derails the entire gluconeogenic pathway. Binding studies with lactate dehydrogenase; Mechanism of inhibition of mitochondrial pyruvate metabolism
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Enzymatic determination of bicarbonate in serum by flow injection analysis
Quiles R, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 235(2), 169-177 (1995)
Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1alpha pathway in chondrocytes
Miao H, et al.
Scientific Reports, 5(20), 13092-13092 (2015)
Otic Antiinfectives-Advances in Research and Application, 56-56 (2013)