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107700

4-(Dimethylamino)pyridine

ReagentPlus®, ≥99%

Synonyme(s) :

N,N-Dimethylpyridin-4-amine, DMAP

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A propos de cet article

Formule empirique (notation de Hill) :
C7H10N2
Numéro CAS:
1122-58-3
Poids moléculaire :
122.17
EC Number:
214-353-5
Beilstein/REAXYS Number:
110354
MDL number:
MFCD00006418
UNSPSC Code:
12352302
NACRES:
NA.22
PubChem Substance ID:
24846774
Assay:
≥99%
Concentration:
≤100%
Form:
chips, crystalline powder, flakes
Grade:
reagent grade
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grade

reagent grade

Quality Segment

200

product line

ReagentPlus®

assay

≥99%

form

chips, crystalline powder, flakes

concentration

≤100%

pH

(10,23 at -0,1 g/l at 22  °C)

bp

162 °C

mp

108-110 °C (lit.)

solubility

H2O: 50 mg/mL

functional group

amine

storage temp.

room temp

SMILES string

CN(C)c1ccncc1

InChI

1S/C7H10N2/c1-9(2)7-3-5-8-6-4-7/h3-6H,1-2H3

InChI key

VHYFNPMBLIVWCW-UHFFFAOYSA-N

General description

4-(Dimethylamino)pyridine (DMAP) is a highly versatile nucleophilic catalyst for acylation reactions and esterifications. It is also employed in various organic transformations like Baylis-Hillman reaction, Dakin-West reaction, protection of amines, C-acylations, silylations, applications in natural products chemistry, and many others.

Application

4-(Dimethylamino)pyridine can be used as a catalyst:
  • To synthesize 3,5-disubstituted 2,6-dicyanoaniline by reacting malononitrile, aldehydes, and β-nitroolefins.
  • For the acylation of alcohols with acid anhydrides under auxiliary base- and solvent-free conditions to synthesize corresponding esters.
  • In Baylis-Hillman reaction to form carbon-carbon bond by the coupling of an activated alkene with an aldehyde or ketone.
A highly efficient catalyst for acylation reactions

Legal Information

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Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 1

target_organs

Nervous system

Classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

255.2 °F

flash_point_c

124 °C

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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