55452
D-α-Hydroxyisovaleric acid
≥98.0% (T)
Synonyme(s) :
(R)-2-Hydroxy-3-methylbutyric acid
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A propos de cet article
Formule empirique (notation de Hill) :
C5H10O3
Numéro CAS:
Poids moléculaire :
118.13
UNSPSC Code:
51113400
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1721139
Assay:
≥98.0% (T)
Form:
solid
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assay
≥98.0% (T)
form
solid
optical activity
[α]20/D −17±1°, c = 1% in chloroform
mp
64-67 °C
functional group
carboxylic acid, hydroxyl
SMILES string
CC(C)[C@@H](O)C(O)=O
InChI
1S/C5H10O3/c1-3(2)4(6)5(7)8/h3-4,6H,1-2H3,(H,7,8)/t4-/m1/s1
InChI key
NGEWQZIDQIYUNV-SCSAIBSYSA-N
Application
D-α-Hydroxyisovaleric acid may be used in the preparation of biodegradable, optically active and isotactic poly(D-2-hydroxy-3-methylbutanoic acid).
Other Notes
This chiral α-hydroxy acid is used for the synthesis of peptides and depsipeptides. It is further used as chiral building block. Synthesis of α-substituted α-hydroxy acids via dioxolanone intermediates.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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R L Johnson
Journal of medicinal chemistry, 23(6), 666-669 (1980-06-01)
The following N-(alpha-hydroxylakanoyl) derivatives of Leu-Val-Phe-OCH3 were synthesized and tested for their ability to inhibit human amniotic renin: D- and L-alpha-hydroxyisocaproyl-Leu-Val-Phe-OCH3, D- and L-alpha-hydroxyisovaleryl-Leu-Val-Phe-OCH3, L-2-hydroxy-3-phenylpropanoyl-Leu-Val-Phe-OCH3, and D- and L-alpha-hydroxyphenylacetyl-Leu-Val-Phe-OCH3. Analysis of the compounds through the use of Dixion plots showed
W. Hartwig et al.
Liebigs Ann. Chem., 1952-1952 (1982)
Hetero-stereocomplex formation between substituted poly (lactic acid) s with linear and branched side chains, poly (l-2-hydroxybutanoic acid) and poly (d-2-hydroxy-3-methylbutanoic acid).
Tsuji H and Hayakawa T.
Polymer, 55(3), 721-726 (2014)