20-133-M
PKC Lipid Activator
Synonyme(s) :
PKC activator, Protein kinase C activator
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A propos de cet article
UNSPSC Code:
41116012
NACRES:
NA.41
eCl@ss:
32160405
Form:
liquid
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liquid
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
NCBI accession no.
UniProt accession no.
Quality Level
Gene Information
human ... PRKCA(5578)
Biochem/physiol Actions
Protein kinase C (PKC) is activated by diacylglycerol (DAG) and acts as an intracellular receptor of tumor-promoting phorbol esters. It regulates several cell functions and signal transduction pathways through cell migration and polarity, differentiation, proliferation, and cell death. PKC is part of a large group of phospholipid-dependent enzymes, which catalyze the covalent transfer of phosphate from ATP to serine and threonine residues of proteins.
Application
For use in kinase assays.
Research Category
All
All
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Protein kinase C (PKC) belongs to a family of serine/ threonine kinases. It comprises a regulatory domain at the N-terminus and a catalytic domain at the C-terminus. The regions are divided into conserved regions (C1–C4) and regions that differ between isoforms (V1–V5). PKC has a common pseudosubstrate domain in the regulatory region.
Physical form
20mM MOPS, pH 7.2, 25mM β-glycerolphosphate, 1mM sodium orthovanadate, 1mM dithiothreitol, 1mM CaCl2.
Preparation Note
1 year at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Classe de stockage
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificats d'analyse (COA)
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
D Breitkreutz et al.
Journal of cancer research and clinical oncology, 133(11), 793-808 (2007-07-31)
The protein kinase C (PKC) family represents a large group of phospholipid dependent enzymes catalyzing the covalent transfer of phosphate from ATP to serine and threonine residues of proteins. Phosphorylation of the substrate proteins induces a conformational change resulting in
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| 20-133A | 04053252362835 |
| 20-133 | 04053252402708 |
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