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Merck

ABC11

Anti-Bax (NT) Antibody

from rabbit

Synonyme(s) :

BCL2-associated X protein, Bcl-2-like protein 4, apoptosis regulator BAX

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A propos de cet article

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, IHC, IP, WB
Citations:
17

Principaux documents

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biological source

rabbit

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

species reactivity (predicted by homology)

bovine (based on 100% sequence homology), feline (based on 100% sequence homology), canine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology)

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

NCBI accession no.

NP_620119

UniProt accession no.

Q07812

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... BAX(581)

General description

BAX (BCL2-associated X protein) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAX protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
The previously assigned protein identifier Q07815 has been merged into Q07812. Full details can be found on the UniProt database.
~ 21 kDa

Immunogen

KLH-conjugated linear peptide corresponding to human BAX at and around the N-terminus.

Application

Anti-Bax Antibody is an antibody against Bax (N-terminus) for use in WB, IP, IC, IH.
Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated BAX from 500 µg of HL60 cell lysate.

Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected BAX in colorectal and ductal carcinoma tissue.

Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected BAX in MCF7 cells.

Biochem/physiol Actions

Rat (90%), Mouse (86%).
This antibody recognizes BAX.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blot in HL60 cell lysate.

Western Blot Analysis: 0.125 µg/ml of this antibody detected BAX on 10 µg of HL60 cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: 06-499

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Classe de stockage

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Adeline Y Robin et al.
Structure (London, England : 1993), 26(10), 1346-1359 (2018-08-21)
BAX and BAK are essential mediators of intrinsic apoptosis that permeabilize the mitochondrial outer membrane. BAX activation requires its translocation from cytosol to mitochondria where conformational changes cause its oligomerization. To better understand the critical step of translocation, we examined
Teruyoshi Saito et al.
Oncology reports, 29(1), 335-342 (2012-11-06)
Hyaluronan (HA), a major component of the extracellular matrix (ECM), is synthesized by HA synthase (HAS) 1, HAS2 and HAS3 and is intricately involved
Dan-Dan Sun et al.
Journal of dental sciences, 18(1), 310-321 (2023-01-17)
Periodontitis is a prevalent infectious inflammatory disease. Growing evidence has revealed important roles for circular RNAs (circRNAs) and circRNA sponge activity in periodontitis. Here, we elucidated the precise part of circ_0097010 in periodontitis pathogenesis. Human periodontal ligament cells (hPDLCs) were
Chloe D Goldsmith et al.
International journal of molecular sciences, 19(7) (2018-07-14)
Current chemotherapy drugs for pancreatic cancer only offer an increase in survival of up to six months. Additionally, they are highly toxic to normal tissues, drastically affecting the quality of life of patients. Therefore, the search for novel agents, which
Jessica Dittmann et al.
Cell death and differentiation, 27(6), 1878-1895 (2019-12-14)
Therapeutic efficacy of first-generation hypomethylating agents (HMAs) is limited in elderly acute myeloid leukemia (AML) patients. Therefore, combination strategies with targeted therapies are urgently needed. Here, we discover that priming with SGI-110 (guadecitabine), a next-generation HMA, sensitizes AML cells to
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Numéro d'article de commerce international

RéférenceGTIN
ABC1104053252331749

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