57400
Acide indole-3-propionique
≥99.0% (T)
Synonyme(s) :
Acide 3-(3-indolyl)propanoïque, IPA
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A propos de cet article
Formule empirique (notation de Hill) :
C11H11NO2
Numéro CAS:
Poids moléculaire :
189.21
UNSPSC Code:
12352106
NACRES:
NA.77
PubChem Substance ID:
EC Number:
212-600-1
Beilstein/REAXYS Number:
147733
MDL number:
Assay:
≥99.0% (T)
Form:
solid
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Laissez-nous vous aiderInChI key
GOLXRNDWAUTYKT-UHFFFAOYSA-N
InChI
1S/C11H11NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6H2,(H,13,14)
SMILES string
OC(=O)CCc1c[nH]c2ccccc12
assay
≥99.0% (T)
form
solid
ign. residue
≤0.1%
mp
~133 °C
Quality Level
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Catégories apparentées
Application
- Elucidating the Interaction of Indole-3-Propionic Acid and Calf Thymus DNA: Multispectroscopic and Computational Modeling Approaches.: This study investigates the binding interaction between indole-3-propionic acid and calf thymus DNA, employing multispectroscopic techniques and computational modeling. The insights gained could lead to a deeper understanding of the molecular mechanisms underpinning the protective effects of this compound on DNA integrity, critical for developing novel therapeutic strategies in biochemistry (Wei Y et al., 2024).
- The Tryptophan Metabolite Indole-3-Propionic Acid Raises Kynurenic Acid Levels in the Rat Brain In Vivo.: This research demonstrates how indole-3-propionic acid, a metabolite of tryptophan, can increase levels of kynurenic acid in the brain, offering potential benefits in neuroprotective strategies and the study of psychiatric disorders. Such findings highlight significant implications for mental health research and therapeutic applications (Sathyasaikumar KV et al., 2024).
- Serum-Derived Bovine Immunoglobulin Promotes Barrier Integrity and Lowers Inflammation for 24 Human Adults Ex Vivo.: This study explores how indole-3-propionic acid impacts inflammatory responses and gut barrier integrity, providing valuable data for nutritional science and clinical applications aimed at reducing gastrointestinal disorders and enhancing overall gut health (Van den Abbeele P et al., 2024).
- The Effect of Type 2 Resistant Starch and Indole-3-Propionic Acid on Ameliorating High-Fat-Diet-Induced Hepatic Steatosis and Gut Dysbiosis.: This publication discusses the beneficial effects of indole-3-propionic acid in conjunction with type 2 resistant starch on reducing hepatic steatosis and correcting gut dysbiosis caused by high-fat diets, pointing to potential dietary interventions for managing obesity and associated metabolic disorders (Yang M et al., 2024).
- Gut microbiome and cardiometabolic comorbidities in people living with HIV.: This review highlights the role of indole-3-propionic acid in modulating the gut microbiome and its potential effects on cardiometabolic health in HIV-positive individuals. The findings suggest a promising avenue for improving the quality of life and health outcomes in this population through microbiome-based interventions (Trøseid M et al., 2024).
Biochem/physiol Actions
Studied as an adjunct to improve perfusion after liver transplant.
Was studied as an adjunct to improve perfusion after liver transplant.
Classe de stockage
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Zhongqi Cheng et al.
Environmental science & technology, 39(19), 7662-7666 (2005-10-26)
Field and laboratory experiments were conducted to study the potential use of Fe filings to remove monomethyl arsenate (MMA) and dimethyl arsenate (DMA) from contaminated waters. Batch experiments show that the affinity of MMAfor Fe filings is comparable to that
F Mandelbaum-Shavit et al.
Antimicrobial agents and chemotherapy, 35(12), 2526-2530 (1991-12-01)
Indole-3-propionic acid (IPA), a phytohormone derivative, is a potent inhibitor of growth of Legionella pneumophila cultivated extracellularly in a chemically defined hypotonic medium and intracellularly in human monocytes. The inhibitory activity turns into bactericidal activity with increasing concentrations. The susceptibility
Bernd Kuhn et al.
Bioorganic & medicinal chemistry letters, 16(15), 4016-4020 (2006-06-02)
In the quest for novel PPARalpha/gamma co-agonists as putative drugs for the treatment of type 2 diabetes and dyslipidemia, we have used a structure-based design approach to identify propionic acids with a 1,5-disubstituted indole scaffold as potent PPARalpha/gamma activators. Compounds
Katja Zuther et al.
Molecular microbiology, 68(1), 152-172 (2008-03-04)
Tryptophan is a precursor for many biologically active secondary metabolites. We have investigated the origin of indole pigments first described in the pityriasis versicolor-associated fungus Malassezia furfur. Some of the identified indole pigments have properties potentially explaining characteristics of the
Bojana Savić et al.
Plant & cell physiology, 50(9), 1587-1599 (2009-07-16)
Two auxin amidohydrolases, BrIAR3 and BrILL2, from Chinese cabbage [Brassica rapa L. ssp. pekinensis (Lour.) Hanelt] were produced by heterologous expression in Escherichia coli, purified, and screened for activity towards N-(indol-3-ylacetyl)-L-alanine (IAA-Ala) and the long-chain auxin-amino acid conjugates, N-[3-(indol-3-yl)propionyl]-L-alanine (IPA-Ala)
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