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A9165

N-Acetyl-L-cysteine

Name: <I>N</I>-Acetyl-<SC>L</SC>-cysteine
Brand: SIGMA

≥99% (TLC), suitable for cell culture, BioReagent

Synonyme(s) :

LNAC, NAC

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A propos de cet article

Formule linéaire :

HSCH₂CH(NHCOCH₃)CO₂H

Numéro CAS:

616-91-1

Poids moléculaire :

163.19

NACRES:

NA.26

PubChem Substance ID:

24891402

UNSPSC Code:

12352209

EC Number:

210-498-3

MDL number:

MFCD00004880

Beilstein/REAXYS Number:

1724426

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Nom du produit

N-Acetyl-L-cysteine, suitable for cell culture, BioReagent

product line

BioReagent

Quality Level

200

assay

≥99% (TLC)

form

powder

technique(s)

cell culture | mammalian: suitable

color

white to off-white

mp

106-108 °C (lit.)

solubility

H₂O: 100 mg/mL (with heating)

storage temp.

2-8°C

SMILES string

CC(=O)N[C@@H](CS)C(O)=O

InChI

1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1

InChI key

PWKSKIMOESPYIA-BYPYZUCNSA-N

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Catégories apparentées

Amino Acids – Building Blocks of Life Science

Biochemicals

Cell Culture Supplements & Reagents

Application

N-Acetyl-L-cysteine has been used as a component of intestinal basal medium for the culture of mouse intestinal stem cells and also as a component of expansion medium.

Biochem/physiol Actions

Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

Classe de stockage

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Derivation and long-term expansion of human endometrial and decidual organoids

Margherita Turco

Protocol Exchange, 2639-2644 (2017)

Isolation, Culture, and Maintenance of Mouse Intestinal Stem Cells

Kevin P. O?Rourke

Bio-protocol, 6(4), e1733-e1733 (2016)

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.

Meritxell Huch et al.

Nature, 494(7436), 247-250 (2013-01-29)

The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as small intestine and colon, stomach and hair follicles. A three-dimensional culture system allows long-term clonal expansion of single Lgr5(+) stem

Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells.

Suzanne M Cloonan et al.

Journal of medicinal chemistry, 58(11), 4494-4505 (2015-05-12)

Ruthenium polypyridyl complexes show great promise as new photodynamic therapy (PDT) agents. However, a lack of detailed understanding of their mode of action in cells poses a challenge to their development. We have designed a new Ru(II) PDT candidate that

The chemistry and biological activities of N-acetylcysteine.

Yuval Samuni et al.

Biochimica et biophysica acta, 1830(8), 4117-4129 (2013-04-27)

N-acetylcysteine (NAC) has been in clinical practice for several decades. It has been used as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication, doxorubicin cardiotoxicity, ischemia-reperfusion cardiac injury, acute respiratory distress syndrome, bronchitis, chemotherapy-induced toxicity

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