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H9636

Hypoxanthine

Name: Hypoxanthine
Brand: SIGMA

powder, suitable for cell culture, BioReagent

Synonyme(s) :

6-Hydroxypurine

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A propos de cet article

Formule empirique (notation de Hill) :

C₅H₄N₄O

Numéro CAS:

68-94-0

Poids moléculaire :

136.11

NACRES:

NA.75

PubChem Substance ID:

24895864

UNSPSC Code:

12352207

EC Number:

200-697-3

MDL number:

MFCD00005725

Beilstein/REAXYS Number:

5811

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Propriétés

Nom du produit

Hypoxanthine, powder, BioReagent, suitable for cell culture

product line

BioReagent

Quality Segment

200

assay

≥99%

form

powder

technique(s)

cell culture | mammalian: suitable

SMILES string

O=C1NC=Nc2nc[nH]c12

InChI

1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

InChI key

FDGQSTZJBFJUBT-UHFFFAOYSA-N

Description

General description

Hypoxanthine (6-hydroxypurine), a purine derivative is a naturally occurring compound. It is the deaminated form of adenine and a breakdown product of adenosine monophosphate (AMP).

Application

Hypoxanthine has been used:

as a supplement in HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) -buffered Roswell park memorial institute (RPMI) to culture Plasmodium falciparum strain IT/FCR3
in the preparation of Dulbecco′s modified eagle′s medium (DMEM) + MXH for the selection of chimeric modified vaccinia virus ankara (MVA)
to generate superoxide anions
to prepare hybridoma selection and maintenance media.

Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.

Biochem/physiol Actions

Hypoxanthine is capable of stimulating cell death. It can also induce reactive oxygen species (ROS). It results in endothelial dysfunction via apoptosis, stimulated by oxidative stress.

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Classe de stockage

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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