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Merck

I3265

Interferon-γ human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), lyophilized powder, suitable for cell culture

Synonyme(s) :

IFN-γ

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD00131391

Nom du produit

Interferon-γ human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), lyophilized powder, suitable for cell culture

biological source

human

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

lyophilized powder

mol wt

~17 kDa

packaging

pkg of 0.1 mg

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg endotoxin

color

white

solubility

water: soluble 1.000 mL, clear, colorless

UniProt accession no.

P01579

storage temp.

−20°C

Quality Level

200

Gene Information

human ... IFNG(3458)

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Catégories apparentées

Analysis Note

The biological activity is measured by a viral resistance assay.

Application

Interferon-γ human has been used:
  • to study the effect of interferon-γ on cultured trophoblasts in absence and presence of fibronectin
  • to analyse factors which participate in the production of antibody microarrays on glass support
  • for ELISA (enzyme-linked immunosorbent assay) method to understand the effect of interferon-γ in human gingival fibroblasts in presence of bacterial challenge

Biochem/physiol Actions

IFNG (interferon-γ) is a type-2 interferon which is produced by Th (T helper cells)-1 lymphocytes, CD8 cytotoxic lymphocytes, natural killer (NK) cells, and natural killer T (NKT) cells. It plays an important role in innate and adaptive immune responses, and helps in defense against bacterial infections, dimorphic yeast and some viral infections. High expression of IFNG is common in many autoimmune diseases, such as systemic lupus erythematosis, Sjögren syndrome, inflammatory bowel disease and multiple sclerosis.

Physical form

Lyophilized from phosphate buffered saline.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000227412
0000227412
079M4071V
059M4178V
046M4075V

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

M J Lappin et al.
Archives of oral biology, 61, 36-43 (2015-10-30)
To investigate the potential effects of IFN-03A5 on the responsiveness of human gingival fibroblasts to bacterial challenge. mRNA and protein expression of CD14, TLR2 and TLR4 in human gingival fibroblasts was detected by quantitative polymerase chain reaction (Q-PCR) and flow
Marielle Kaplan et al.
Inflammation, 41(4), 1477-1487 (2018-04-25)
Arterial macrophages comprise a heterogeneous population: pro-inflammatory (M1) and anti-inflammatory (M2). Since C-reactive protein (CRP) is produced by macrophages in atherosclerotic lesions, understanding of CRP regulation in macrophages could be crucial to decipher inflammatory patterns in atherogenesis. We aimed to
Wlad Kusnezow et al.
Proteomics, 3(3), 254-264 (2003-03-11)
Antibody microarrays could have an enormous impact on the functional analysis of cellular activity and regulation, especially at the level of protein expression and protein-protein interaction, and might become an invaluable tool in disease diagnostics. The array surface is bound
K Pfizenmaier et al.
Cancer research, 45(8), 3503-3509 (1985-08-01)
The effect of recombinant gamma-interferon (IFN-gamma) on established human colon carcinoma cell lines as well as fresh tumor cells from colon carcinoma patients has been investigated with respect to growth inhibition, enhancement of HLA expression, and modulation of immunogenicity. A
R Pijnenborg et al.
Molecular human reproduction, 6(7), 635-641 (2000-06-29)
Tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma, produced by maternal inflammatory cells, may compromise trophoblast survival at the trophoblast-maternal interface and notably in the placental bed which is invaded by trophoblast. Extracellular matrix components, e.g. fibronectin, may enhance trophoblast survival.
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Contenu apparenté

Data Sheet - I3265

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