P215
PD 98,059
MAPKK inhibitor, solid
Synonyme(s) :
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059
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A propos de cet article
Formule empirique (notation de Hill) :
C16H13NO3
Numéro CAS:
Poids moléculaire :
267.28
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
Service technique
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Laissez-nous vous aiderNom du produit
PD 98,059, solid
form
solid
Quality Level
color
yellow
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
SMILES string
COc1cccc(c1N)C2=CC(=O)c3ccccc3O2
InChI
1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
InChI key
QFWCYNPOPKQOKV-UHFFFAOYSA-N
Gene Information
Application
PD 98,059 has been used:
- in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors
- in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown
- in culture medium for cell migration assay
Biochem/physiol Actions
PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.
Features and Benefits
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Legal Information
Sold with permission of Warner Lambert Company.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Contenu apparenté
Sepsis: Advances in Research and Treatment: 2011 Edition, 38-38 (2012)
Epidermal CFTR suppresses MAPK/NF-kappaB to promote cutaneous wound healing
Chen J
Cellular Physiology and Biochemistry, 39(6), 2262-2274 (2016)
Extracellular Matrix Proteins: Advances in Research and Application (2012)