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Merck

943541

AP1867-2-(carboxymethoxy)

≥95%

Synonym(s):

(1R)-1-[2-(Carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate, 2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-1-[2-(carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)-

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form

crystalline powder

reaction suitability

reaction type: Amidations, reaction type: Esterifications

storage condition

protect from light

color

white to beige

storage temp.

−20°C

SMILES string

O=C(O)COC=1C=CC=CC1C(OC(=O)C2N(C(=O)C(C3=CC(OC)=C(OC)C(OC)=C3)CC)CCCC2)CCC4=CC=C(OC)C(OC)=C4

InChI key

UYXSZUBFOQLRNQ-BTIIJPOSSA-N

InChI

1S/C38H47NO11/c1-7-26(25-21-33(46-4)36(48-6)34(22-25)47-5)37(42)39-19-11-10-13-28(39)38(43)50-30(27-12-8-9-14-29(27)49-23-35(40)41)17-15-24-16-18-31(44-2)32(20-24)45-3/h8-9,12,14,16,18,20-22,26,28,30H,7,10-11,13,15,17,19,23H2,1-6H3,(H,40,41)/t26-,28-,30+/m0/s1

assay

≥95%

Quality Level

100

General description

Ortho AP1867 is a selective binding ligand for the single point mutant FKBP12 F36V, designed with an ortho-position carboxymethoxy modification (hence “ortho”) to provide an ‘exit vector’ for downstream chemical conjugation. It is primarily used as a precursor in the dTAG™ (degradation tag) system, enabling controlled degradation of tagged proteins by recruiting the E3 ligase complex when coupled with a matching ligand.

Application

  • dTAG system / targeted protein degradation: Used as the binding ligand component in bifunctional degraders (PROTAC-type molecules) that recruit FKBP12 F36V-tagged proteins for proteasomal degradation.
  • Chemical biology tool: As a modular building block for constructing degrader molecules, chemical probes, and studying protein knockdown dynamics.
  • Drug discovery & functional genomics: Useful for validation of disease targets via induced degradation of tagged proteins.

Features and Benefits

  • High affinity ligand for FKBP12 F36V: Enables selective binding to the engineered FKBP12 mutant, which is central to the dTAG system for induced degradation.
  • Functionalised with a carboxylic acid ‘exit vector’: The ortho position acid allows further chemical derivatisation (e.g., coupling to warheads/linkers) without interfering with the ligand binding region.

Legal Information

Tough-Tags is a trademark of Diversified Biotech

signalword

Warning

hcodes

H315

pictograms

Exclamation mark
GHS07

Hazard Classifications

Skin Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000522990
0000522990

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