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Merck

MAGPMAG-24K

MILLIPLEX® Mouse Angiogenesis/Growth Factor Panel 1

Configurable Mouse Angiogenesis/Growth Factor 27-Plex Panel 1

Synonym(s):

Luminex mouse angiogenesis assay, Millipore mouse angiogenesis panel, mouse growth factor multiplex kit, mouse multiplex cancer panel, mouse oncology kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000
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species reactivity

mouse

Quality Level

assay range

accuracy: 90-104%, standard curve range: 1-1,000 pg/mL
(Endothelin-1), standard curve range: 137-100,000 pg/mL
(Follistatin), standard curve range: 137-100,000 pg/mL
(HGF), standard curve range: 137-100,000 pg/mL
(SDF-1), standard curve range: 14-10,000 pg/mL
(IL-1b), standard curve range: 14-10,000 pg/mL
(Leptin), standard curve range: 14-10,000 pg/mL
(MIP-1α), standard curve range: 14-10,000 pg/mL
(sALK-1), standard curve range: 14-10,000 pg/mL
(sCD31/ PECAM-1), standard curve range: 27-20,000 pg/mL
(Angiopoietin-2), standard curve range: 27-20,000 pg/mL
(EGF), standard curve range: 27-20,000 pg/mL
(Endoglin), standard curve range: 27-20,000 pg/mL
(MCP-1), standard curve range: 27-20,000 pg/mL
(VEGF-C), standard curve range: 3-2,000 pg/mL
(PLGF-2), standard curve range: 6-4,000 pg/mL
(TNFα), standard curve range: 6-4,000 pg/mL
(VEGF-A), standard curve range: 69-50,000 pg/mL
(FGF-2/FGF-basic), standard curve range: 69-50,000 pg/mL
(Prolactin), standard curve range: 69-50,000 pg/mL
(VEGF-D), standard curve range: 69-50,000 pg/mL
(sFasL), standard curve range: 7-5,000 pg/mL
(Amphiregulin), standard curve range: 7-5,000 pg/mL
(Betacellulin), standard curve range: 7-5,000 pg/mL
(G-CSF), standard curve range: 7-5,000 pg/mL
(IL-17A), standard curve range: 7-5,000 pg/mL
(IL-6), standard curve range: 7-5,000 pg/mL
(KC/CXCL1)

technique(s)

multiplexing: suitable

input

cell culture supernatant(s)

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

General description

Angiogenesis, the development of new vascular networks, is a key process in normal growth and development as well as in wound healing, with homeostasis maintained by a delicate balance of angiogenic factors and inhibitors. Consequently, insufficient, or excessive blood vessel growth underlies many diseases, including cardiovascular disease, diabetic ulcers, macular degeneration, and cancer. Angiogenesis plays a significant role in tumor growth and metastasis.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 27 analytes in mouse serum, plasma, cell culture supernatants, and cell/tissue extracts.

Analytes included: sALK-1, Amphiregulin, Angiopoietin-2, Betacellulin, sCD31/sPECAM-1, EGF, Endoglin, Endothelin-1, sFasL, FGF-2 (FGF-basic), Follistatin (FST), G-CSF, HGF, IL-1β, IL-6, IL-17A (CTLA8), KC (GRO/CINC-1/CXCL1), Leptin, MCP-1 (CCL2), MIP-1α (CCL3), Placental Growth Factor 2 (PLGF-2), Prolactin, SDF-1 (CXCL12), TNF-α, VEGF-A, VEGF-C, VEGF-D

Note: Sample type must be selected when configuring this kit. Angiopeoitin-2, Betacellulin, and PECAM-1 should not be run in serum/plasma samples.

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

Multiplex Capability: Simultaneous quantification of up to 24 analytes in serum/plasma or 27 analytes in cell culture samples, including key angiogenesis and growth factors such as VEGF-A, TNFα, IL-6, FGF-2, and more.

Wide Dynamic Range: Standard curve ranges vary by analyte, covering low to high pg/mL concentrations.

Flexible Sample Types: Compatible with mouse serum, plasma, tissue/cell culture supernatants or lysates.

Supports Studies on Tumor Microenvironment: Helps investigate how hypoxia, inflammation, and cytokine signaling contribute to abnormal vascularization in tumors.

Supports Translational Research: Enables biomarker discovery in mouse models that mimic human disease, supporting translational studies in oncology, inflammation, and vascular biology.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

10 - Combustible liquids

wgk

WGK 3


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Wenjie Li et al.
Stem cells international, 2022, 8540535-8540535 (2022-06-18)
Adipose-derived stem cells (ASCs) improve the self-renewal and survival of fat grafts in breast reconstruction after oncology surgery. However, ASCs have also been found to enhance breast cancer growth, and its role in tumor proliferation remains largely elusive. Here, we
Aziza R Alrafiah
Biomedicines, 9(9) (2021-09-29)
The present study focused on secondary injury following the middle cerebral artery (MCA) occlusion in rats not linked to the MCA's feeding zone. This entity has been very rarely studied. Additionally, this study investigated the rates of expression of five
Sara Luscieti et al.
Blood, 130(17), 1934-1945 (2017-08-05)
Cellular iron homeostasis is controlled by the iron regulatory proteins (IRPs) 1 and 2 that bind cis-regulatory iron-responsive elements (IRE) on target messenger RNAs (mRNA). We identified profilin 2 (Pfn2) mRNA, which encodes an actin-binding protein involved in endocytosis and
Pier-Anne Lachance et al.
PloS one, 8(9), e76078-e76078 (2013-10-03)
During acute inflammation, functioning lymphatics are believed to reduce edema and to provide a transiting route for immune cells, but the extent at which the dermal lymphatic remodeling impacts lymphatic transport or the factors regulating these changes remains unclear. Herein
Sneha Sundaram et al.
Anticancer research, 39(4), 1729-1738 (2019-04-07)
Monocyte chemotactic protein-1 (MCP1) is a potent adipokine. This study tested the hypothesis that adipose-produced MCP1 contributes to metastasis. In a spontaneous metastasis model of Lewis lung carcinoma (LLC), male adipose MCP1-deficient (Mcp1-/-) and wild-type (WT) mice were fed the

Global Trade Item Number

SKUGTIN
MAGPMAG-24K-1004053252857263
MAGPMAG-24K-1104053252857270
MAGPMAG-24K-0204053252857188
MAGPMAG-24K-0504053252857218
MAGPMAG-24K-0704053252857232
MAGPMAG-24K-0404053252857201
MAGPMAG-24K-0104053252857171
MAGPMAG-24K-0904053252857256
MAGPMAG-24K-1704053252857331
MAGPMAG-24K-1904053252857355
MAGPMAG-24K-2204053252857386
MAGPMAG-24K-2504053252857416
MAGPMAG-24K-1504053252857317
MAGPMAG-24K-2104053252857379
MAGPMAG-24K-2304053252857393
MAGPMAG-24K-2604053252857423
MAGPMAG-24K-1304053252857294
MAGPMAG-24K-0804053252857249
MAGPMAG-24K-1204053252857287
MAGPMAG-24K-1404053252857300
MAGPMAG-24K-0304053252857195
MAGPMAG-24K-1804053252857348
MAGPMAG-24K-1604053252857324
MAGPMAG-24K-2004053252857362

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