34218
Cefuroxime
VETRANAL®, analytical standard
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About This Item
Empirical Formula (Hill Notation):
C16H16N4O8S
CAS Number:
Molecular Weight:
424.39
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
259-560-1
MDL number:
grade
analytical standard
Quality Level
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
clinical testing
format
neat
storage temp.
2-8°C
SMILES string
[H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@H]2NC(=O)\C(=N/OC)c3ccco3)C(O)=O
InChI
1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9-/t10-,14-/m1/s1
InChI key
JFPVXVDWJQMJEE-IZRZKJBUSA-N
General description
Chemical structure: β-lactam
Cefuroxime is a new broad-spectrum cephalosporin antibiotic, with increased stability to β-lactamases. It is actively used against gram-positive organisms, including penicillinase-producing staphylococci and non-β-lactamase-producing gram-negative bacteria.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Cefuroxime may be used as a reference standard in the determination of cefuroxime in plasma samples using high-performance liquid chromatography (HPLC).(3)
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
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Cefuroxime: human pharmacokinetics.
Foord DR.
Antimicrobial Agents and Chemotherapy, 9(5), 741-747 (1976)
Till Junker et al.
Swiss medical weekly, 142, w13616-w13616 (2012-09-06)
Surgical site infections (SSI) are the most common hospital-acquired infections among surgical patients, with significant impact on patient morbidity and health care costs. The Basel SSI Cohort Study was performed to evaluate risk factors and validate current preventive measures for
Shiri Zarour et al.
American journal of surgery, 214(3), 456-461 (2017-02-27)
Cholecystectomy is the standard of care in acute cholecystitis (AC). Percutaneous cholecystostomy (PC) is an effective alternative for high-risk surgical cases. A retrospective analysis is presented of AC patients treated with PC drainage at a single tertiary institution over a