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B5274

Bupivacaine hydrochloride monohydrate

analytical standard, for drug analysis

Synonym(s):

1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C18H28N2O · HCl · H2O
CAS Number:
73360-54-0
Molecular Weight:
342.90
NACRES:
NA.24
PubChem Substance ID:
329773253
UNSPSC Code:
41116107
EC Number:
241-917-8
MDL number:
MFCD00941462
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Quality Level

100

assay

≥99%

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

O.Cl.CCCCN1CCCCC1C(=O)Nc2c(C)cccc2C

InChI

1S/C18H28N2O.ClH.H2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3;;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H;1H2

InChI key

HUCIWBPMHXGLFM-UHFFFAOYSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Bupivacaine hydrochloride monohydrate may be used as an analytical standard for the determination of the bupivacaine in pharmaceutical preparations and plasma samples using chromatography techniques.

Biochem/physiol Actions

Sodium channel blocker, local anesthetic.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCBZ5207
BCBW8645
BCBM7058V
BCBQ9309V
BCBQ9309

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Related Content

Data Sheet - B5274

Product Information Sheet

Determination of free concentration of ropivacaine and bupivacaine in blood plasma by ultrafiltration and coupled-column liquid chromatography
Arvidsson T and Eklund E
Journal of Chromatography. B, Biomedical Sciences and Applications, 668(1), 91-98 (1995)
Arnaud Chaumeron et al.
Clinical orthopaedics and related research, 471(7), 2284-2295 (2013-03-22)
The postoperative analgesic potential of periarticular anesthetic infiltration (PAI) after TKA is unclear as are the complications of continuous femoral nerve block on quadriceps function. We asked (1) whether PAI provides equal or improved postoperative pain control in comparison to
Huiyuan Zhang et al.
Drug design, development and therapy, 13, 1659-1666 (2019-06-14)
Background: Bupivacaine (Bup) is the most commonly used local anesthetic. However, Bup induces cytotoxicity, especially in older patients. Recent reports have indicated that andrographolide (Andro) exhibits protective effects on human neurons. Nevertheless, whether Andro can inhibit Bup-induced cytotoxicity remains unclear.
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