00541
Ruthenium Red
85.0-115.0% (calc. on dry basis, AT)
Synonym(s):
Ammoniated ruthenium oxychloride
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About This Item
Linear Formula:
[(NH3)5RuORu(NH3)4ORu(NH3)5]Cl6
CAS Number:
Molecular Weight:
786.35
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12171500
MDL number:
Colour Index Number:
77800
Quality Level
assay
85.0-115.0% (calc. on dry basis, AT)
form
powder
impurities
~5% water
solubility
water: 10 mg/mL, clear to turbid
εmax
≥150 at 529-539 nm
suitability
suitable for microscopy
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
SMILES string
N.N.N.N.N.N.N.N.N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru++]O[Ru++]O[Ru++]
InChI
1S/6ClH.14H3N.2O.3Ru/h6*1H;14*1H3;;;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6
InChI key
ZXYSDUPLHOJIOR-UHFFFAOYSA-H
General description
Ruthenium red is an inorganic cationic dye. It is also known as ammoniated ruthenium oxychloride. It is a large coordination complex consisting of three metal atoms connected by bridging oxygens, in addition to multiple amine ligands.
Application
Inhibits mitochondrial Ca2+ uniporter; capsaicin antagonist; blocks VR1 vanilloid receptor-coupled ion channels.
Ruthenium red is suitable for use in light microscopy to stain pectins. It is also used to stain glycosaminoglycans by employing a two-color staining method with alcian blue. It serves as a typical basic dye at a higher pH that stains nuclei, Nissl substance, cartilage matrix, and mast cell granules. Other applications involving light microscopy include staining resin-embedded material. Ruthenium red is an important component of fixatives of the bacterial glycocalyx.
Biochem/physiol Actions
Ruthenium red inhibits mitochondrial Ca2+ uniporter. It is a known capsaicin antagonist. Additionally, it is known to block VR1 vanilloid receptor-coupled ion channels.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
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