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Merck

P5891

L-Pyroglutamic acid 2-naphthylamide

≥99% (TLC), suitable for ligand binding assays

Synonym(s):

L-Pyroglutamic acid β-naphthylamide, L-Pyrrolidonyl-β-naphthylamide, N1-(2-Naphthyl)-L-pyroglutamic acid, PYR

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About This Item

Empirical Formula (Hill Notation):
C15H14N2O2
CAS Number:
22155-91-5
Molecular Weight:
254.28
NACRES:
NA.26
PubChem Substance ID:
329820238
UNSPSC Code:
12352209
EC Number:
244-809-9
MDL number:
MFCD00055911
Beilstein/REAXYS Number:
5066652

Key Documents

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Product Name

L-Pyroglutamic acid 2-naphthylamide, ≥99% (TLC)

InChI key

BZEPQNMASTUAMY-ZDUSSCGKSA-N

InChI

1S/C15H14N2O2/c18-14-8-7-13(17-14)15(19)16-12-6-5-10-3-1-2-4-11(10)9-12/h1-6,9,13H,7-8H2,(H,16,19)(H,17,18)/t13-/m0/s1

SMILES string

O=C1CC[C@H](N1)C(=O)Nc2ccc3ccccc3c2

assay

≥99% (TLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

storage temp.

2-8°C

Quality Level

200

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Biochem/physiol Actions

Pyroglutamic acid is known to participate in the gamma-glutamyl cycle. Recent studies show that a congenital metabolic error was associated with increased pyroglutamic excretion in urine.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

A substrate for pyroglutamate aminopeptidase. Used for differentiation of Group A streptococci and enterococci from other streptococci.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H400

pcodes

P273

Hazard Classifications

Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM2607
BCCL7839
BCCK9253
BCCH0964
BCCJ1028

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Jean-Sébastien Jouhanneau et al.
Nature communications, 9(1), 1540-1540 (2018-04-20)
A defining feature of cortical layer 2/3 excitatory neurons is their sparse activity, often firing in singlets of action potentials. Local inhibitory neurons are thought to play a major role in regulating sparseness, but which cell types are recruited by
S Santisi et al.
Journal of applied microbiology, 127(3), 618-629 (2019-03-09)
The aims of this study were: (i) the characterization of the structure of the indigenous microbial community associated with the sediments under study; (ii) the isolation and characterization of microbial consortia able to degrade the aged hydrocarbons contaminating the sediments
C A Barboza et al.
Scientific reports, 9(1), 2481-2481 (2019-02-23)
Inflammatory processes and cardiovascular autonomic imbalance are very relevant characteristic of the enormous dynamic process that is a myocardial infarction (MI). In this sense, some studies are investigating pharmacological therapies using acetylcholinesterase inhibitors, such as pyridostigmine bromide (PYR), aiming to
Takahiro Tougan et al.
Malaria journal, 18(1), 8-8 (2019-01-16)
The erythrocytic stage of Plasmodium falciparum parasites in humans is clinically important, as the parasites at this growth stage causes malarial symptoms. Most of the currently available anti-malarial drugs target this stage, but the emergence and spread of parasites resistant
Studies on the Accumulation of L-Pyroglutamic Acid in Guinea Pig Epidermis
Sverre MarsteinM.D.
The Journal of Investigative Dermatology, 74(3), 135-138 (1980)
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