SCP0064
cAMP Dependent PKI Peptide
≥95% (HPLC), lyophilized powder
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About This Item
Empirical Formula (Hill Notation):
C85H149N31O24
Molecular Weight:
1989.29
UNSPSC Code:
12352202
NACRES:
NA.32
Product Name
cAMP Dependent Protein Kinase Inhibitor PKI-tide,
assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥67%
storage condition
protect from light
storage temp.
−20°C
Application
IAAGRTGRRQAIHDILVAA is used as a cAMP-dependent protein kinase inhibitory peptide.
Biochem/physiol Actions
cAMP dependent protein kinase inhibitors are generally designed to target the synthesis and degradation of cAMP (cyclic adenosine monophophaphate), a second messenger.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Barbara Wienen-Schmidt et al.
ChemMedChem, 16(1), 292-300 (2020-10-09)
In lead optimization, protein crystallography is an indispensable tool to analyze drug binding. Binding modes and non-covalent interaction inventories are essential to design follow-up synthesis candidates. Two protocols are commonly applied to produce protein-ligand complexes: cocrystallization and soaking. Because of
Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design
Taylor SS, et al.
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1784(1), 16-26 (2008)
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